Microglia activation in the spinal cord play a major role in the pathogenesis of neuropathic
pain. The p38 mitogen-activated protein kinase (MAPK) regulates microglia activation …

Nucleoside reverse transcriptase inhibitors (NRTIs), drugs used to treat HIV infection, can
cause neuropathic pain (NP) and neuroinflammation. An NRTI, 2′-3′-dideoxycytidine …

Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …

Several drugs and agents are currently used for the treatment of neuropathic pain. Among
them amitriptyline, a tricyclic antidepressant drug, represent a first line treatment. Despite its …

To elucidate the underlying mechanisms involved in AIDS therapy-induced peripheral
neuropathy, we have developed a model of nucleoside analog reverse transcriptase …

Chemotherapy-induced peripheral neuropathy (CIPN) is the most common side-effect of anti-
cancer therapy. To date, there are no clinically effective analgesics that could prevent and …

Although antiretroviral agents have been used successfully in suppressing viral production,
they have also been associated with a number of side effects. The antiretroviral toxic …

Background Accumulating evidence on the causal role of spinal cord microglia activation in
the development of neuropathic pain after peripheral nerve injury suggests that microglial …

Paclitaxel is a commonly used cancer chemotherapy drug that frequently causes painful
peripheral neuropathies. The mechanisms underlying this dose-limiting side effect are …

Oxaliplatin-induced peripheral neuropathy (OIPN) is a serious side effect that impairs the
quality of life of patients treated with the chemotherapeutic agent, oxaliplatin. The underlying …