Dysregulation of steroid hormone receptors in motor neurons and glia associates with disease progression in ALS mice
VM McLeod, MDF Chiam, CL Lau… - …, 2020 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease targeting motor neurons
which shows sexual dimorphism in its incidence, age of onset, and progression rate. All …
which shows sexual dimorphism in its incidence, age of onset, and progression rate. All …
[HTML][HTML] Mapping Motor Neuron Vulnerability in the Neuraxis of Male SOD1G93A Mice Reveals Widespread Loss of Androgen Receptor Occurring Early in Spinal …
Sex steroid hormones have been implicated as disease modifiers in the neurodegenerative
disorder amyotrophic lateral sclerosis (ALS). Androgens, signalling via the androgen …
disorder amyotrophic lateral sclerosis (ALS). Androgens, signalling via the androgen …
[HTML][HTML] Dissociation of disease onset, progression and sex differences from androgen receptor levels in a mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder caused by
loss of motor neurons. ALS incidence is skewed towards males with typically earlier age of …
loss of motor neurons. ALS incidence is skewed towards males with typically earlier age of …
Androgens affect muscle, motor neuron, and survival in a mouse model of SOD1-related amyotrophic lateral sclerosis
T Aggarwal, MJ Polanco, C Scaramuzzino… - Neurobiology of …, 2014 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
selective loss of upper and lower motor neurons and skeletal muscle atrophy. Epidemiologic …
selective loss of upper and lower motor neurons and skeletal muscle atrophy. Epidemiologic …
Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis
VM McLeod, CL Lau, MDF Chiam… - British Journal of …, 2019 - Wiley Online Library
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative
disease typically more common in males, implicating androgens in progression of both …
disease typically more common in males, implicating androgens in progression of both …
Gonadectomy and dehydroepiandrosterone (DHEA) do not modulate disease progression in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis
A Hayes-Punzo, P Mulcrone, M Meyer… - Amyotrophic Lateral …, 2012 - Taylor & Francis
Epidemiological studies have shown a higher incidence of amyotrophic lateral sclerosis
(ALS) in men than women. Interestingly, there are clear gender differences in disease onset …
(ALS) in men than women. Interestingly, there are clear gender differences in disease onset …
Effect of sex on lifespan, disease progression, and the response to methionine sulfoximine in the SOD1 G93A mouse model for ALS
M Bame, PA Pentiak, R Needleman, WSA Brusilow - Gender medicine, 2012 - Elsevier
OBJECTIVE: To investigate the role of sex and the role of ammonia and amino acid
metabolism, specifically the activity of glutamine synthetase, in survival and disease …
metabolism, specifically the activity of glutamine synthetase, in survival and disease …
Characterization of aromatase expression in the spinal cord of an animal model of familial ALS
C Sun, Y Liu, Y Liu, M Zhao, J Zhai, P Hao, Y Wang… - Brain Research …, 2017 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease involving motor neurons
in the motor cortex, brainstem and spinal cord. ALS leads to progressive, aggravated muscle …
in the motor cortex, brainstem and spinal cord. ALS leads to progressive, aggravated muscle …
Sexual dimorphism in disease onset and progression of a rat model of ALS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease causing the
progressive loss of brain and spinal cord motor neurons. The exact etiology of ALS is still …
progressive loss of brain and spinal cord motor neurons. The exact etiology of ALS is still …
[HTML][HTML] Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43A315T Mouse Model of Amyotrophic Lateral …
Amyotrophic lateral sclerosis (ALS) attacks the corticomotor system, with motor cortex
function affected early in disease. Younger females have a lower relative risk of succumbing …
function affected early in disease. Younger females have a lower relative risk of succumbing …