The NLRC4 inflammasome is part of the human immune innate system. Its activation leads
to the cleavage of pro-inflammatory cytokines IL-1β and IL-18, promoting inflammation …

Gain of function (GOF) mutations affecting the inflammasome component NLRC4 are known
to cause early-onset macrophage activation syndrome (MAS) and neonatal enterocolitis …

Background NOD-like receptor family CARD-containing 4 protein (NLRC4) is a cytosolic
protein that forms an inflammasome in response to flagellin and type 3 secretion system …

Inflammasomes are cytosolic multiprotein complexes that sense microbial infections or host
cell damage, triggering cytokine production and a proinflammatory form of cell death, called …

Autoinflammatory disorders are characterized by dysregulated innate immune response,
resulting in recurrent uncontrolled systemic inflammation and fever. Gain-of-function …

Upon detection of pathogen-associated molecular patterns, innate immune receptors initiate
inflammatory responses. These receptors include cytoplasmic NOD-like receptors (NLRs) …

Background: The NLRP3 inflammasome has been recognized as one of the key
components of innate immunity. Gain-of-function mutations in the exon 3 of NLRP3 gene …

Background Very-early-onset inflammatory bowel disease (VEOIBD) is a chronic
inflammatory disease of the gastrointestinal tract occurring during infancy or early childhood …

The NLRC4 inflammasome mediates the rapid release of proinflammatory cytokines in
response to various microbial stimuli, but its role in the pathology of human diseases …

Inflammasomes are innate immune sensors that respond to pathogen-and damage-
associated signals with caspase-1 activation, interleukin (IL)-1β and IL-18 secretion, and …