Spleen and lymphoid organs are important targets for messenger RNA (mRNA) delivery in
various applications. Current nanoparticle delivery methods rely on drainage to lymph …

Introduction: Adoptive cell transfer (ACT) of T cells has emerged in recent years as a
powerful immunotherapy against cancer. Currently, T cells are harvested from the patient or …

Conventional vaccines have saved millions of lives, and new vaccines have also been
developed; however, an urgent need for an efficient vaccine against SARS-CoV-2 showed …

Dendritic cells (DCs) are attractive antigen-presenting cells to be targeted for vaccinations.
However, the systemic delivery of mRNA to DCs is hampered by technical challenges. We …

With the deepening of our understanding of adaptive immunity at the cellular and molecular
level, targeting antigens directly to immune cells has proven to be a successful strategy to …

The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
has had a profound impact on the global health and economy. While mass vaccination for …

Nucleic acid vaccines are a method of immunization aiming to elicit immune responses akin
to live attenuated vaccines. In this method, DNA or messenger RNA (mRNA) sequences are …

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells (APCs) and
evaluate their potential to be used as a vaccine delivery system. Materials & methods …

Messenger RNA vaccines lack specificity for dendritic cells (DCs)—the most effective cells at
antigen presentation. Here we report the design and performance of a DC-targeting virus …

Background Dendritic cell (DC) targeted antigen delivery is a promising strategy to enhance
vaccine efficacy and delivery of therapeutics. Self-assembling peptide-based nanoparticles …