Nowadays, multidrug resistance and side effects of drugs limit the effectiveness of
chemotherapies in clinics. P-glycoprotein (P-gp)(MDR1), as a member of the ATP-binding …

Background Acquired drug resistance is becoming common during cancer chemotherapy
and leads to treatment failure in clinic. To conquer acquired drug resistance …

Abstract Background Tyrosine kinase inhibitors (TKIs) that act against the epithelial growth
factor receptor (EGFR) were once widely used in chemotherapy for many human cancers …

Aim: This work aims to develop an injectable nano-drug delivery system to overcome tumor
multidrug resistance (MDR). Methods: A drug delivery nanoplatform based on PEGylated …

Background Autophagy reportedly plays vital and complex roles in many diseases. During
times of starvation or energy deficiency, autophagy will occur at higher levels to provide cells …

Chemotherapy is the mainstay in cancer treatment; however, its application is clinically
limited to patients with multidrug resistance (MDR). MDR reverses the role of chemotherapy …

Chemotherapy-induced multi-drug resistance (MDR) in tumors poses a huge challenge for
clinical treatment of tumors. The downregulation of the multi-drug resistance relative protein …

Over expression of drug efflux transporters such as P-glycoprotein (P-gp) cumulatively
leading to multidrug resistance (MDR) embodies a major hindrance for successful cancer …

Arise of multidrug resistance in cancer cells is a major obstacle for effective cancer
chemotherapy. Multi-drug resistant (MDR) may be treated using combinations of …

To increase the efficacy of small molecule chemotherapeutic drug (SMCD) and reduce its
toxic and side effects, we selected two model drugs doxorubicin (DOX) and chloroquine …