Healthy adipose tissue expansion and metabolism during weight gain require coordinated
angiogenesis and lymphangiogenesis. These vascular growth processes rely on the …

Leong-Poi Yin and Yang of VEGF in Obesity 1035 in adipose tissue, and was found to
strongly correlate with reduced capillary growth. Coimmunoprecipitation experiments …

White and brown adipose tissues are hypervascularized and the adipose vasculature
displays phenotypic and functional plasticity to coordinate with metabolic demands of …

The prevalence of overweight and obesity has become a global epidemic, with more than 1
billion people affected worldwide, particularly in low-and middle-income countries (LMICs) …

Obesity has reached epidemic proportions and is a major contributor to insulin resistance
(IR) and type 2 diabetes (T2D). Importantly, IR and T2D substantially increase the risk of …

Impaired angiogenesis has been implicated in adipose tissue dysfunction and the
development of obesity and associated metabolic disorders. Here, we report the unexpected …

Obesity is an ever-increasing phenomenon, with 42% of Americans being considered obese
(BMI≥ 30) and 9.2% being considered morbidly obese (BMI≥ 40) as of 2016. With obesity …

Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …

Adipose tissue (AT) is a highly vascularized endocrine organ which regulates whole-body
metabolic homeostasis. Key AT functions which rely on vascularization include insulin …

Angiogenesis plays an instrumental role in the modulation of adipose tissue mass and
metabolism. Targeting adipose vasculature provides an outstanding opportunity for …