Longitudinal metabolomic analysis of plasma enables modeling disease progression in Duchenne muscular dystrophy mouse models

R Tsonaka, M Signorelli, E Sabir, A Seyer… - Human Molecular …, 2020 - academic.oup.com
Duchenne muscular dystrophy is a severe pediatric neuromuscular disorder caused by the
lack of dystrophin. Identification of biomarkers is needed to support and accelerate drug …

The metabolomic plasma profile of patients with Duchenne muscular dystrophy: providing new evidence for its pathogenesis

H Xu, X Cai, K Xu, Q Wu, B Xu - Orphanet Journal of Rare Diseases, 2023 - Springer
Background Duchenne muscular dystrophy (DMD) is a fatal genetic muscle-wasting disease
that affects 1 in 5000 male births with no current cure. Despite great progress has been …

Discovery of metabolic biomarkers for Duchenne muscular dystrophy within a natural history study

SM Boca, M Nishida, M Harris, S Rao, AK Cheema… - PloS one, 2016 - journals.plos.org
Serum metabolite profiling in Duchenne muscular dystrophy (DMD) may enable discovery of
valuable molecular markers for disease progression and treatment response. Serum …

Dystrophinopathy-associated dysfunction of Krebs cycle metabolism

A Lindsay, CM Chamberlain… - Human Molecular …, 2019 - academic.oup.com
Duchenne muscular dystrophy is a deadly muscle-wasting disorder caused by loss of
dystrophin protein. Studies suggest that metabolic alterations are important to disease …

Circulating biomarkers for Duchenne muscular dystrophy

A Aartsma-Rus, P Spitali - Journal of neuromuscular diseases, 2015 - content.iospress.com
Duchenne muscular dystrophy is the most common form of muscular dystrophy. Genetic and
biochemical research over the years has characterized the cause, pathophysiology and …

Applications of metabolomics and proteomics to the mdx mouse model of Duchenne muscular dystrophy: lessons from downstream of the transcriptome

JL Griffin, C Des Rosiers - Genome medicine, 2009 - Springer
Functional genomic studies are dominated by transcriptomic approaches, in part reflecting
the vast amount of information that can be obtained, the ability to amplify mRNA and the …

Multiomic characterization of disease progression in mice lacking dystrophin

M Signorelli, R Tsonaka, A Aartsma-Rus, P Spitali - PLoS One, 2023 - journals.plos.org
Duchenne muscular dystrophy (DMD) is caused by genetic mutations leading to lack of
dystrophin in skeletal muscle. A better understanding of how objective biomarkers for DMD …

Metabolomic analyses reveal extensive progenitor cell deficiencies in a mouse model of Duchenne muscular dystrophy

J Joseph, DS Cho, JD Doles - Metabolites, 2018 - mdpi.com
Duchenne muscular dystrophy (DMD) is a musculoskeletal disorder that causes severe
morbidity and reduced lifespan. Individuals with DMD have an X-linked mutation that impairs …

Multiomics analysis of the mdx/mTR mouse model of Duchenne muscular dystrophy

DW Van Pelt, YA Kharaz, DC Sarver… - Connective Tissue …, 2021 - Taylor & Francis
ABSTRACT Purpose/Aim Duchenne muscular dystrophy (DMD) is a progressive
neuromuscular disease characterized by extensive muscle weakness. Patients with DMD …

Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle

MSV Lorena, EK Santos, R Ferretti, GA Nagana Gowda… - Skeletal Muscle, 2023 - Springer
Background Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy
without an effective treatment, caused by mutations in the DMD gene, leading to the …