[HTML][HTML] Rodent models of amyloid-beta feature of Alzheimer's disease: development and potential treatment implications

CH Poon, Y Wang, ML Fung, C Zhang… - Aging and disease, 2020 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide and
causes severe financial and social burdens. Despite much research on the pathogenesis of …

[HTML][HTML] Mouse models of Alzheimer's disease

M Yokoyama, H Kobayashi, L Tatsumi… - Frontiers in Molecular …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …

Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions

M Kitazawa, R Medeiros… - Current pharmaceutical …, 2012 - ingentaconnect.com
Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no
effective treatment is available for AD. Analysis of transgenic mouse models of AD has …

Animal and cellular models of Alzheimer's disease: Progress, promise, and future approaches

L Trujillo-Estrada, E Sanchez-Mejias… - The …, 2022 - journals.sagepub.com
Alzheimer's disease (AD) is an incurable neurodegenerative disease affecting over 45
million people worldwide. Transgenic mouse models have made remarkable contributions …

[HTML][HTML] Animal models of Alzheimer's disease: preclinical insights and challenges

QQ Xu, W Yang, M Zhong, ZX Lin, NE Gray… - Acta Materia …, 2023 - scienceopen.com
Alzheimer's disease (AD), an irreversible neurodegenerative disease that progressively
impairs memory and cognitive judgment, severely affects the quality of life and imposes a …

Past to future: what animal models have taught us about Alzheimer's disease

AC Martini, S Forner, L Trujillo-Estrada… - Journal of …, 2018 - content.iospress.com
Alzheimer's disease (AD) impairs memory and causes significant cognitive deficits. The
disease course is prolonged, with a poor prognosis, and thus exacts an enormous economic …

Genetically modified mice models for Alzheimer's disease

S Sankaranarayanan - Current Topics in Medicinal Chemistry, 2006 - ingentaconnect.com
Transgenic mice models for Alzheimer's disease (AD) are essential to the understanding of
disease pathophysiology, develop robust behavioral models and predict outcomes from …

Selecting a mouse model of Alzheimer's disease

J Chin - … Disease and Frontotemporal Dementia: Methods and …, 2011 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease and cause of
dementia. Significant strides toward understanding and developing therapies for AD have …

Recent rodent models for Alzheimer's disease: clinical implications and basic research

N Braidy, P Munoz, AG Palacios… - Journal of neural …, 2012 - Springer
Alzheimer's disease (AD) is the most common origin of dementia in the elderly. Although the
cause of AD remains unknown, several factors have been identified that appear to play a …

[HTML][HTML] Mammalian Models in Alzheimer's Research: An Update

H Sharma, KA Chang, J Hulme, SSA An - Cells, 2023 - mdpi.com
A form of dementia distinct from healthy cognitive aging, Alzheimer's disease (AD) is a
complex multi-stage disease that currently afflicts over 50 million people worldwide …