Animal models of disease are valuable resources for investigating pathogenic mechanisms
and potential therapeutic interventions. However, for complex disorders such as Alzheimer's …

Alzheimer's disease (AD) is the most common neurodegenerative affliction of the elderly,
presenting with progressive memory loss and dementia and terminating with death. There …

Most mouse models for preclinical research into Alzheimer's disease (AD) rely on the
overexpression paradigm, in which familial AD (FAD)-related genes linked to amyloid …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Alzheimer disease (AD) is a chronic, progressive disorder with an average disease
progression of 7–10 years. However, the histopathological hallmark lesions of this disease …

Alzheimer's disease (AD) is a devastating neurodegenerative disease that affects more than
15 million people worldwide. Within the next generation, these numbers will more than …

Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder. It
is widely accepted that AD is mainly caused by the accumulation of extracellular amyloid β …

Alzheimer's disease (AD) is the most common form of dementia. At the diagnostic stage, the
AD brain is characterized by the accumulation of extracellular amyloid plaques, intracellular …

During the last few decades, numerous stable transgenic mouse strains have been
developed in order to mimic a range of Alzheimer's disease (AD)-related pathologies …

Alzheimer's disease (AD) is one of the most important neurodegenerative disorders,
bringing about huge medical and social burden in the elderly worldwide. Many aspects of its …