Alzheimer's disease (AD) is one of the most important neurodegenerative disorders,
bringing about huge medical and social burden in the elderly worldwide. Many aspects of its …

The prevalence of neurodegenerative diseases, particularly those that affect the aged, are
predicted to increase rapidly in the coming decades. The World Health Organization …

Over the past decade the process of inflammation has been a focus of increasing interest in
the Alzheimer's disease (AD) field, not only for its potential role in neuronal degeneration but …

Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

Alzheimer's disease (AD), the most common neurodegenerative and dementing disorder, is
characterized by extracellular amyloid deposition, intracellular neurofibrillary tangle …

The success of biomedical researches has led to improvement in human health and
increased life expectancy. An unexpected consequence has been an increase of age …

Transgenic mouse models represent an essential tool for the exploration of Alzheimer's
disease (AD) pathological mechanisms and the development of novel treatments, which at …

During the past 2 decades, the elucidation of susceptibility and causative genes for
Alzheimer disease as well as proteins involved in the pathogenic process has greatly …

A robust preclinical disease model is a primary requirement to understand the underlying
mechanisms, signaling pathways, and drug screening for human diseases. Although various …

This review describes several transgenic mouse models of Alzheimer's disease (AD), a
devastating neurodegenerative disorder that causes progressive cognitive decline and is …