Successful disease modifying drug development for Alzheimer's disease (AD) has hit a
roadblock with the recent failures of amyloid-based therapies, highlighting the translational …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common form of dementia worldwide. As age is the main risk factor,> 97% of all AD cases …

▪ Abstract Alzheimer's disease (AD), the most common dementing disorder of late life, is a
major cause of disability and death in the elderly. Neurobiological, genetic, and molecular …

Animal models of Alzheimer's disease (AD) have been extensively utilized for decades in an
effort to elucidate the pathophysiological mechanisms of this disease and to test novel …

Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …

Over 5 million Americans and 50 million individuals worldwide are living with Alzheimer's
disease (AD). The progressive dementia associated with AD currently has no cure. Although …

Amyloidopathies cause neurodegeneration in a substantial portion of the elderly population.
Improvements in long term health care have made elderly individuals a large and growing …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. The main
pathogenic features are the development and deposition of senile plaques and …

The continuing failure to develop an effective treatment for Alzheimer's disease urges a
better understanding of the pathogenic mechanisms and the improvement of current animal …

Animal models have contributed significantly to our understanding of the underlying
biological mechanisms of Alzheimer's disease (AD). As a result, over 300 interventions have …