[HTML][HTML] Progranulin as a therapeutic target in neurodegenerative diseases
Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
[HTML][HTML] Microglial progranulin: involvement in Alzheimer's disease and neurodegenerative diseases
A Mendsaikhan, I Tooyama, DG Walker - Cells, 2019 - mdpi.com
Neurodegenerative diseases such as Alzheimer's disease have proven resistant to new
treatments. The complexity of neurodegenerative disease mechanisms can be highlighted …
treatments. The complexity of neurodegenerative disease mechanisms can be highlighted …
Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β
Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …
Progranulin in neurodegenerative disease
TL Petkau, BR Leavitt - Trends in neurosciences, 2014 - cell.com
Loss-of-function mutations in the progranulin gene are a common cause of familial
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …
Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease
BP Chitramuthu, HPJ Bennett, A Bateman - Brain, 2017 - academic.oup.com
Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …
Progranulin: normal function and role in neurodegeneration
JL Eriksen, IRA Mackenzie - Journal of neurochemistry, 2008 - Wiley Online Library
Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …
neuroscience community following the recent discovery of PGRN mutations in some cases …
Structure, function, and mechanism of progranulin; the brain and beyond
H Toh, BP Chitramuthu, HPJ Bennett… - Journal of Molecular …, 2011 - Springer
Mutation of human GRN, the gene encoding the secreted glycoprotein progranulin, results in
a form of frontotemporal lobar degeneration that is characterized by the presence of …
a form of frontotemporal lobar degeneration that is characterized by the presence of …
A brief overview of progranulin in health and disease
A Bateman, ST Cheung, HPJ Bennett - Progranulin: Methods and …, 2018 - Springer
The purpose of this brief overview of the progranulin protein is to provide a sense of the
range and extent of the roles of progranulin in normal physiology and pathology …
range and extent of the roles of progranulin in normal physiology and pathology …
[HTML][HTML] Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia
MJ Simon, T Logan, SL DeVos, G Di Paolo - Trends in Cell Biology, 2023 - cell.com
Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …
[HTML][HTML] Progranulin in frontotemporal lobar degeneration and neuroinflammation
Z Ahmed, IRA Mackenzie, ML Hutton… - Journal of …, 2007 - Springer
Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …
community with recent discoveries of mutations in the gene for PGRN that cause …