The discovery that heterozygous and homozygous mutations in the gene encoding
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …

Haploinsufficiency of the progranulin (PGRN) gene (GRN) causes familial frontotemporal
lobar degeneration (FTLD) and modulates an innate immune response in humans and in …

Progranulin deficiency is thought to cause some forms of frontotemporal dementia (FTD), a
major early-onset age-dependent neurodegenerative disease. How progranulin (PGRN) …

Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and
experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked …

Loss-of-function mutations in GRN cause frontotemporal dementia (FTD) with transactive
response DNA-binding protein of 43 kD (TDP-43)–positive inclusions and neuronal ceroid …

Background Progranulin is a secreted high molecular weight growth factor bearing seven
and one half copies of the cysteine-rich granulin-epithelin motif. While inappropriate over …

Mutations in the progranulin gene (GRN) are an important cause of frontotemporal lobar
degeneration (FTLD) with ubiquitin and TAR DNA-binding protein 43 (TDP43)-positive …

Loss-of-function mutations in progranulin, a lysosomal glycoprotein, cause
neurodegenerative disease. Progranulin haploinsufficiency causes frontotemporal dementia …

Progranulin (PGRN) is a growth factor involved in wound healing, inflammation, tumor
growth, and neurodegeneration. Mutations in the gene encoding PGRN give rise to shortage …

Background The essential role of progranulin (PGRN) as a neurotrophic factor has been
demonstrated by the discovery that haploinsufficiency due to GRN gene mutations causes …