The growth factor progranulin (PGRN) regulates cell division, survival, and migration. PGRN
is an extracellular glycoprotein bearing multiple copies of the cysteine‐rich granulin motif …

Highlights•PGRN is a growth factor with pleiotropic actions.•PGRN shows potential as a
biomarker in different diseases.•Attstrin (a PGRN-derived peptide) is a potential therapeutic …

Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in
social and emotional function. Heterozygous loss-of-function mutations in GRN, the …

Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are
overlapping neurodegenerative disorders. Mutations in the growth factor progranulin …

J. Neurochem.(2010) 112, 1305–1315. Abstract Frontotemporal dementia with ubiquitin‐
positive inclusions (FTLD‐U) can be caused by mutations in the progranulin gene (GRN) …

Frontotemporal dementia (FTD) is a clinical term encompassing dementia characterized by
the presence of two major phenotypes: 1) behavioral and personality disorder, and 2) …

Frontotemporal lobar degeneration is a fatal neurodegenerative disease that results in
progressive decline in behavior, executive function and sometimes language. Disease …

Progranulin (PGRN) haploinsufficiency resulting from loss-of-function mutations in the
PGRN gene causes frontotemporal lobar degeneration accompanied by TDP-43 …

Background Progranulin (PGRN), a widely secreted growth factor, is involved in multiple
biological functions, and mutations located within the PGRN gene (GRN) are a major cause …

Frontotemporal lobar degeneration is a progressive neurodegenerative syndrome that is the
second most common cause of early-onset dementia. Mutations in the progranulin gene are …