Chronic inflammation drives colitis-associated colorectal cancer (CAC) in inflammatory
bowel disease (IBD). FoxP3+ regulatory T cells (Treg) coexpressing the Th17-related …

Colorectal cancer (CRC) is associated with loss of epithelial barrier integrity, which
facilitates the interaction of the immunological microenvironment with the luminal …

Most colorectal cancer (CRC) patients are insensitive to immune checkpoint inhibitors (ICIs)
due to the immunosuppressive tumor microenvironment (TME). Epigenetic factors such as …

Immune infiltration has been correlated with survival of patients with colorectal cancer. In this
issue, Ziegler et al. reveal complex and unexpected connections between loss of STAT3 …

Background Recent advances in immune checkpoint blockade (ICB) have improved patient
prognosis in mismatch repair-deficient and microsatellite instability-high colorectal cancer …

Cancer immunity is regulated by several mechanisms that include co-stimulatory and/or co-
inhibitory molecules known as immune checkpoints expressed by the immune cells. In …

Colorectal cancer (CRC) is a heterogeneous disease with one of the highest rates of
incidence and mortality among cancers worldwide. Understanding the CRC tumor …

Increased tumor infiltrating lymphocytes (TIL) are associated with improved patient
responses to immunotherapy. As a result, there is interest in enhancing lymphocyte …

Regulatory T cells (Tregs), a subset of CD4+ or CD8+ T cells, play a pivotal role in regulating
immune homeostasis. An increase in Tregs was reported in many tumors to be associated …

Simple Summary Colorectal cancer is one of the leading causes of global cancer-related
mortality. Tumor-infiltrating effector immune cells play critical roles in tumor control, and their …