Colorectal cancer (CRC) represents one of the most common causes of death among
cancers worldwide. Its incidence has been increasing among the young population. Many …

The density and type of lymphocytes that infiltrate colon tumors are predictive of the clinical
outcome of colon cancer. High densities of TH17 cells and inflammation predict poor …

Background Immune cells play an integral role in the prevention as well as the progression
of cancers. Within the T cell compartment, regulatory T cells (T regs) suppress the anti-tumor …

Purpose Immune checkpoint blockade (ICB) therapy shows little or no clinical benefit in most
colorectal cancer (CRC) patients, due to the immunosuppressive T cell contexture in the …

Background Recent advances in immune checkpoint blockade (ICB) have improved patient
prognosis in mismatch repair-deficient and microsatellite instability-high colorectal cancer …

Simple Summary Colorectal cancer is one of the leading causes of global cancer-related
mortality. Tumor-infiltrating effector immune cells play critical roles in tumor control, and their …

Tumor cells undergoing epithelial to mesenchymal transition (EMT) and immune cells in
tumor microenvironment (TME) reciprocally influence each other. Natural killer (NK) cells …

The tumor microenvironment includes a complex network of immune T-cell subpopulations.
In this study, we systematically analyzed the balance between cytotoxic T cells and different …

Background Elevated tumor-infiltrating lymphocytes (TILs) within the tumor
microenvironment is a known positive prognostic factor in colorectal cancer (CRC). We …

Cancer immunity is regulated by several mechanisms that include co-stimulatory and/or co-
inhibitory molecules known as immune checkpoints expressed by the immune cells. In …