Regulatory T cells (Treg) play a key role in maintaining the balance of immune responses in
human health and in disease. Treg come in many flavors and can utilize a variety of …

Background Macrophage infiltration is crucial for colorectal cancer (CRC) immunotherapy.
Detailed classification of macrophage subsets will facilitate the selection of patients suitable …

Background Cytotoxic CD8+ T cell-mediated response is the most important arm of adaptive
immunity, which dictates the capacity of the host immune response in eradicating tumor …

Purpose PIK3CA mutation or overexpression is associated with immunotherapy resistance
in multiple cancer types, but is also paradoxically associated with benefit of COX-2 inhibition …

Regulatory T (Treg) cells play a crucial role in maintaining self‐tolerance and resolution of
immune responses by employing multifaceted immunoregulatory mechanisms. However …

3620 Background: Colorectal cancer (CRC) is divided into 2 groups based on genomic
differences: chromosomal instability (80%), and microsatellite instability (MSI)(20%). MSI …

The immune system plays a pivotal role in the development and progression of colorectal
cancer (CRC). Tumor immune rejection has been previously linked to the activation of the …

Extrinsic factors such as expression of PD-L1 (programmed dealth-ligand 1) in the tumor
microenvironment (TME) have been shown to correlate with responses to checkpoint …

There are different subsets of T regulatory cells (Tregs), orchestrating critical roles in the
regulation of anti-tumor immunity in colorectal cancer (CRC). In this study, we report that a …

A hypoxic tumor microenvironment is linked to poor prognosis. It promotes tumor cell
dedifferentiation and metastasis and desensitizes tumor cells to type-I IFN, chemotherapy …