Rhein enhances the cytotoxicity of effector lymphocytes in colon cancer under hypoxic conditions
X Yuan, W Tian, Y Hua, L Hu… - Experimental and …, 2018 - spandidos-publications.com
The immunosuppressive tumor microenvironment limits the application of adoptive
immunotherapy for solid tumors. Hypoxia is closely associated with the formation of the …
immunotherapy for solid tumors. Hypoxia is closely associated with the formation of the …
Hypoxia induces transcriptional and translational downregulation of the type I IFN pathway in multiple cancer cell types
A Miar, E Arnaiz, E Bridges, S Beedie, AP Cribbs… - Cancer research, 2020 - AACR
Hypoxia is a common phenomenon in solid tumors and is strongly linked to hallmarks of
cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type …
cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type …
Intratumoral FoxP3+Helios+ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer
Regulatory T cells (Tregs) can be antitumorigenic or pro-tumorigenic in colorectal cancer
(CRC) depending on the presence of different Treg subsets with various …
(CRC) depending on the presence of different Treg subsets with various …
The Role of the JAK/STAT Signalling Pathway in Immunoregulation of Gastrointestinal Cancers
K Vaddi - Immunotherapy for Gastrointestinal Cancer, 2017 - Springer
Targeting the immune system as a major therapeutic modality for the treatment of cancer has
finally come of age, with immune checkpoint inhibitors leading the way. Better …
finally come of age, with immune checkpoint inhibitors leading the way. Better …
[HTML][HTML] The trouble with TRIBbles: TRIB3 blocks CD8 T cell homing to colorectal cancers
RA Clark - Science Immunology, 2022 - science.org
The trouble with TRIBbles: TRIB3 blocks CD8 T cell homing to colorectal cancers | Science
Immunology news careers commentary Journals Science Science brought to you byGoogle …
Immunology news careers commentary Journals Science Science brought to you byGoogle …
STAT6 is critical for the induction of regulatory T cells in vivo controlling the initial steps of colitis-associated cancer
Y Delgado-Ramirez, A Ocaña-Soriano… - International Journal of …, 2021 - mdpi.com
Inflammation is the main driver of the tumor initiation and progression in colitis-associated
colorectal cancer (CAC). Recent findings have indicated that the signal transducer and …
colorectal cancer (CAC). Recent findings have indicated that the signal transducer and …
The Shc protein Rai enhances T‐cell survival under hypoxia
M Criscuoli, C Ulivieri, I Filippi, S Monaci… - Journal of Cellular …, 2020 - Wiley Online Library
Hypoxia occurs in physiological and pathological conditions. T cells experience hypoxia in
pathological and physiological conditions as well as in lymphoid organs. Indeed, hypoxia …
pathological and physiological conditions as well as in lymphoid organs. Indeed, hypoxia …
Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development
A Varveri, M Papadopoulou, Z Papadovasilakis… - Nature …, 2024 - nature.com
Cancer-associated fibroblasts (CAFs) have emerged as a dominant non-hematopoietic cell
population in the tumour microenvironment, serving diverse functions in tumour progression …
population in the tumour microenvironment, serving diverse functions in tumour progression …
The molecular mechanism of actions and clinical utilities of tumor infiltrating lymphocytes in gastrointestinal cancers: a comprehensive review and future prospects …
M Piroozkhah, Y Gholinezhad, M Piroozkhah… - Frontiers in …, 2023 - frontiersin.org
Gastrointestinal (GI) cancers remain a significant global health burden, accounting for a
substantial number of cases and deaths. Regrettably, the inadequacy of dependable …
substantial number of cases and deaths. Regrettably, the inadequacy of dependable …
[HTML][HTML] Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies
S Koyama, H Nishikawa - Journal for immunotherapy of cancer, 2021 - ncbi.nlm.nih.gov
With the broad application of cancer immunotherapies such as immune checkpoint inhibitors
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …