[HTML][HTML] From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?

RC Silva, HS Domingues, AJ Salgado… - Neural Regeneration …, 2022 - journals.lww.com
Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.
Clinically, it is characterized by severe motor complications caused by progressive …

Cell secretome based approaches in Parkinson's disease regenerative medicine

CR Marques, A Marote… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: The available therapeutic strategies for Parkinson's disease (PD) rely only on
the amelioration of the symptomatology of the disease, lacking neuroprotection or …

Secretome of undifferentiated neural progenitor cells induces histological and motor improvements in a rat model of Parkinson's disease

B Mendes-Pinheiro, FG Teixeira, SI Anjo… - Stem cells …, 2018 - academic.oup.com
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that
results from the death of dopamine (DA) neurons. Over recent years, differentiated or …

[HTML][HTML] Insights into the effects of mesenchymal stem cell-derived secretome in Parkinson's disease

M d'Angelo, A Cimini, V Castelli - International Journal of Molecular …, 2020 - mdpi.com
Mesenchymal stem cell (MSC)-derived secretome demonstrated therapeutic effects like
those reported after MSCs transplantation. MSC-derived secretome may avoid various side …

[HTML][HTML] Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in a Parkinson's disease rat model

B Mendes-Pinheiro, SI Anjo, B Manadas… - … in bioengineering and …, 2019 - frontiersin.org
Parkinson's disease (PD) is characterized by a selective loss of dopamine (DA) neurons in
the human midbrain causing motor dysfunctions. The exact mechanism behind …

[HTML][HTML] Treating Parkinson's Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and …

B Mendes-Pinheiro, J Campos, A Marote… - Cells, 2023 - mdpi.com
Parkinson's disease (PD) is the most common movement disorder, characterized by the
progressive loss of dopaminergic neurons from the nigrostriatal system. Currently, there is …

Stem-cell-based strategies for the treatment of Parkinson's disease

CL Parish, E Arenas - Neurodegenerative Diseases, 2007 - karger.com
Background: Cell transplantation to replace lost neurons in neurodegenerative diseases
such as Parkinson's disease (PD) offers a hopeful prospect for many patients. Previously …

[图书][B] Stem cell therapy for Parkinson's disease

F Han, B Hu - 2020 - Springer
Parkinson's disease (PD) is one of the most common neurodegenerative diseases caused
by specific degeneration and loss of dopamine neurons in substantia nigra of the midbrain …

Old and new challenges in Parkinson's disease therapeutics

AO Pires, FG Teixeira, B Mendes-Pinheiro… - Progress in …, 2017 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the
degeneration of dopaminergic neurons and/or loss od neuronal projections, in several …

Fractionating stem cells secretome for Parkinson's disease modeling: Is it the whole better than the sum of its parts?

H Vilaça-Faria, A Marote, I Lages, C Ribeiro… - Biochimie, 2021 - Elsevier
Human mesenchymal stem cells (hMSCs) secretome has been have been at the forefront of
a new wave of possible therapeutic strategies for central nervous system neurodegenerative …