Fractionating stem cells secretome for Parkinson's disease modeling: Is it the whole better than the sum of its parts?

H Vilaça-Faria, A Marote, I Lages, C Ribeiro… - Biochimie, 2021 - Elsevier
Human mesenchymal stem cells (hMSCs) secretome has been have been at the forefront of
a new wave of possible therapeutic strategies for central nervous system neurodegenerative …

New therapeutic approaches to Parkinson's disease including neural transplants

WL Kuan, RA Barker - Neurorehabilitation and neural repair, 2005 - journals.sagepub.com
Parkinson's disease (PD) is a common neurodegenerative disorder of the brain and typically
presents with a disorder of movement. The core pathological event underlying the condition …

Progress in dopaminergic cell replacement and regenerative strategies for Parkinson's disease

W Chen, Q Huang, S Ma, M Li - ACS Chemical Neuroscience, 2018 - ACS Publications
Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder
symptomatically characterized by resting tremor, rigidity, bradykinesia, and gait impairment …

Emerging treatment approaches for Parkinson's disease

TB Stoker, KM Torsney, RA Barker - Frontiers in neuroscience, 2018 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disease,
manifesting as a characteristic movement disorder with a number of additional non-motor …

Impact of the secretome of human mesenchymal stem cells on brain structure and animal behavior in a rat model of Parkinson's disease

FG Teixeira, MM Carvalho… - Stem cells …, 2017 - academic.oup.com
Research in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated
therapeutic benefits are mainly due to their secretome, which has been proposed as a …

Cell therapy in Parkinson's disease: host brain repair machinery gets a boost from stem cell grafts

E Napoli, CV Borlongan - Stem Cells, 2017 - academic.oup.com
This commentary highlights the major findings and future research directions arising from
the recent publication by Zuo and colleagues in Stem Cells 2017 (in press). Here, we …

Neuroregeneration in Parkinson's Disease: From proteins to small molecules

YA Sidorova, KP Volcho… - Current …, 2019 - ingentaconnect.com
Background: Parkinson's disease (PD) is the second most common neurodegenerative
disorder worldwide, the lifetime risk of developing this disease is 1.5%. Motor diagnostic …

Stem Cell-Based Approaches in Parkinson's Disease Research.

MS Kim, S Yoon, J Choi, YJ Kim… - International Journal of …, 2024 - europepmc.org
Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of
midbrain dopaminergic neurons, leading to motor symptoms. While current treatments …

The secretome of mesenchymal stem cells: potential implications for neuroregeneration

G Paul, SV Anisimov - Biochimie, 2013 - Elsevier
Mesenchymal stem cells have shown regenerative properties in many tissues. This feature
had originally been ascribed to their multipotency and thus their ability to differentiate into …

Modern therapeutic approaches in Parkinson's disease

SJG Lewis, MA Caldwell, RA Barker - Expert reviews in molecular …, 2003 - cambridge.org
Parkinson's disease (PD) is a common neurodegenerative disorder of the brain and typically
presents with a disorder of movement. The core pathological event underlying the condition …