Background Chronic vascular disease atherosclerosis starts with an uptake of atherogenic
modified low‐density lipoproteins (LDLs) by resident macrophages, resulting in formation of …

Atherosclerosis is a complex disease that involves alterations in lipoprotein metabolism and
inflammation. Protein and lipid glycosylation events, such as sialylation, contribute to the …

Desialylation of low density lipoprotein (LDL) brings about accumulation of cholesterol in
cultured cells. The influence of the neuraminidase-treated lipoprotein (LP) on the reverse …

Rationale: Plasma cholesterol lowering is beneficial in patients with atherosclerosis.
However, it is unknown how it affects entry and degradation of low-density lipoprotein (LDL) …

Sialic acid (Sia), the acylated derivative of the nine-carbon sugar neuraminic acid, is a
terminal component of the oligosaccharide chains of many glycoproteins and glycolipids. In …

Atherosclerosis is a chronic inflammatory disease [1, 2] which manifests in the pathological
thickening of the walls of large arteries, and is related to lipid depositions. Lipids, including …

Lipoprotein metabolism is an important contributing factor in the development and
progression of atherosclerosis. Plasma lipoproteins and their receptors are heavily …

Oxidation and lipolytic remodeling of LDL are believed to stimulate LDL entrapment in the
arterial wall, expanding the inflammatory response and promoting atherosclerosis. However …

Deficit sialylation of vascular endothelium, circulating cells and macromolecules has been
associated with the development of atherosclerosis. On the other hand, an elevated serum …

Objective—Enzyme-modified nonoxidized low-density lipoprotein (ELDL) is present in
human atherosclerotic lesions. Our objective is to understand the mechanisms of ELDL …