Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk.
APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk …

Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …

Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …

In this review, evidence is provided that apolipoprotein E (apoE) genotype accounts for the
majority of Alzheimer's disease (AD) risk and pathology. The three major human isoforms …

Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

There are three isoforms of the 33-kDa protein apolipoprotein E (apoE), termed apoE2,
apoE3, and apoE4, each encoded by distinct genes APOE2, APOE3, and APOE4 …

The ɛ4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's
disease (AD). Although there have been numerous studies attempting to elucidate the …

Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

One of the primary genetic risk factors for Alzheimer's disease (AD) is the presence of the Ɛ4
allele of apolipoprotein E (APOE). APOE is a polymorphic lipoprotein that is a major …

Human apolipoprotein (apo) E, long known for its prominent role in cholesterol transport and
plasma lipoprotein metabolism, has recently emerged as a major genetic risk factor for …