The interplay between zinc and iron homeostasis in Aspergillus fumigatus under zinc‐replete conditions relies on the iron‐mediated regulation of alternative transcription units of …

R Vicentefranqueira, F Leal, L Marín… - Environmental …, 2019 - Wiley Online Library
Aspergillus fumigatus is a saprophyte fungus that typically grows on organic decaying matter
but can also parasitize immunosuppressed hosts. This is explained, in part, by its great …

Aspergillus fumigatus survival in alkaline and extreme zinc-limiting environments relies on the induction of a zinc homeostasis system encoded by the zrfC and aspf2 …

J Amich, R Vicentefranqueira, F Leal, JA Calera - Eukaryotic cell, 2010 - Am Soc Microbiol
Aspergillus fumigatus has three zinc transporter-encoding genes whose expression is
regulated by both pH and the environmental concentration of zinc. We have previously …

Cadmium uptake and subcellular compartmentation in the ectomycorrhizal fungus Paxillus involutus

D Blaudez, B Botton, M Chalot - Microbiology, 2000 - microbiologyresearch.org
Cadmium uptake and subcellular compartmentation in the ectomycorrhizal fungus Paxillus
involutus were investigated using radiotracer flux analyses. Concentration-dependent Cd2+ …

[HTML][HTML] The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages

M Schrettl, O Ibrahim-Granet, S Droin, M Huerre… - Microbes and …, 2010 - Elsevier
Iron plays a central role in manifestation of infections for a variety of pathogens. To ensure
an adequate supply with iron, Aspergillus fumigatus employs extra-and intracellular …

Iron and copper as virulence modulators in human fungal pathogens

C Ding, RA Festa, TS Sun, ZY Wang - Molecular microbiology, 2014 - Wiley Online Library
Fungal pathogens have evolved sophisticated machinery to precisely balance the fine line
between acquiring essential metals and defending against metal toxicity. Iron and copper …

Identification of key proteins and pathways in cadmium tolerance of Lactobacillus plantarum strains by proteomic analysis

Q Zhai, Y Xiao, J Zhao, F Tian, H Zhang, A Narbad… - Scientific Reports, 2017 - nature.com
Our previous study confirmed the protective potential of Lactobacillus plantarum (L.
plantarum) strains in alleviation of cadmium (Cd) toxicity in vivo and demonstrated that the …

The Transcription Factor ZafA Regulates the Homeostatic and Adaptive Response to Zinc Starvation in Aspergillus fumigatus

R Vicentefranqueira, J Amich, L Marín, CI Sánchez… - Genes, 2018 - mdpi.com
One of the most important features that enables Aspergillus fumigatus to grow within a
susceptible individual and to cause disease is its ability to obtain Zn2+ ions from the …

[HTML][HTML] Copper homeostasis in Aspergillus fumigatus: opportunities for therapeutic development

J Song, R Li, J Jiang - Frontiers in microbiology, 2019 - frontiersin.org
Aspergillus fumigatus can cause severe invasive aspergillosis in immunocompromised
individuals. Copper, an essential but potentially toxic trace element for A. fumigatus, plays a …

Transcriptional response of Aspergillus fumigatus to copper and the role of the Cu chaperones

D Anabosi, Z Meir, Y Shadkchan, M Handelman… - Virulence, 2021 - Taylor & Francis
Aspergillus fumigatus is the leading cause of life-threatening invasive mold infections in
immunocompromised individuals. This ubiquitous saprophyte possesses several natural …

A Putative Mitochondrial Iron Transporter MrsA in Aspergillus fumigatus Plays Important Roles in Azole-, Oxidative Stress Responses and Virulence

N Long, X Xu, H Qian, S Zhang, L Lu - Frontiers in microbiology, 2016 - frontiersin.org
Iron is an essential nutrient and enzyme co-factor required for a wide range of cellular
processes, especially for the function of mitochondria. For the opportunistic fungal pathogen …