Amiodarone (AMI) is a potent antiarrhythmic drug. In vivo and in vitro, AMI is biotransformed
to mono-N-desethylamiodarone (MDEA). Recently, it was observed that MDEA was further …

Amiodarone (AMI) is a potent antiarrhythmic drug, but its metabolism has not yet been fully
documented. Mono-N-desethylamiodarone (MDEA) is its only known metabolite. Our …

1. Amiodarone (AMI) is a potent anti-arrhythmic drug and mono-N-desethylamiodarone
(MDEA) is its only known metabolite. It was found recently that in rabbit liver microsomes …

In mammals, mono-N-desethylamiodarone (MDEA) is the only known metabolite of
amiodarone. Our previous experiments demonstrated that in vitro MDEA may be …

A selective and sensitive assay for amiodarone N-deethylation activity in human liver
microsomes by high-performance liquid chromatography (HPLC) with UV detection is …

Identification of an amiodarone metabolite in the plasma of patients receiving a single dose
of the drμg was carried out by mass-spectrometry following extraction and HPLC separation …

A simple and sensitive high-performance liquid chromatographic method for the
simultaneous assay of amiodarone and desethylarniodarone in plasma, urine and tissues …

A rapid and sensitive high-performance liquid chromatography (HPLC) method was
developed and validated in rat plasma and tissue (heart, liver, kidney and lung) …

A reversed-phase high-performance liquid chromatographic assay using ultraviolet
detection is described for determining the production of the major N-dealkylated metabolite …

A liquid chromatographic‐mass spectrometry (LC/MS) assay method was developed for the
determination of amiodarone and desethylamiodarone in rat specimens. Analytes were …