Metabolism of amiodarone: II. High-performance liquid chromatographic assay for mono-N-desethylamiodarone hydroxylation in liver microsomes
HR Ha, P Kozlik, B Stieger, L Bigler, F Follath - Journal of Chromatography …, 2001 - Elsevier
Amiodarone (AMI) is a potent antiarrhythmic drug. In vivo and in vitro, AMI is biotransformed
to mono-N-desethylamiodarone (MDEA). Recently, it was observed that MDEA was further …
to mono-N-desethylamiodarone (MDEA). Recently, it was observed that MDEA was further …
Metabolism of amiodarone (part I): identification of a new hydroxylated metabolite of amiodarone
HR Ha, L Bigler, M Binder, P Kozlik, B Stieger… - Drug metabolism and …, 2001 - ASPET
Amiodarone (AMI) is a potent antiarrhythmic drug, but its metabolism has not yet been fully
documented. Mono-N-desethylamiodarone (MDEA) is its only known metabolite. Our …
documented. Mono-N-desethylamiodarone (MDEA) is its only known metabolite. Our …
Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone
P Kozlik, HR Ha, B Stieger, L Bigler, F Follath - Xenobiotica, 2001 - Taylor & Francis
1. Amiodarone (AMI) is a potent anti-arrhythmic drug and mono-N-desethylamiodarone
(MDEA) is its only known metabolite. It was found recently that in rabbit liver microsomes …
(MDEA) is its only known metabolite. It was found recently that in rabbit liver microsomes …
Identification and quantitation of novel metabolites of amiodarone in plasma of treated patients
HR Ha, L Bigler, B Wendt, M Maggiorini… - European journal of …, 2005 - Elsevier
In mammals, mono-N-desethylamiodarone (MDEA) is the only known metabolite of
amiodarone. Our previous experiments demonstrated that in vitro MDEA may be …
amiodarone. Our previous experiments demonstrated that in vitro MDEA may be …
High-performance liquid chromatographic assay for amiodarone N-deethylation activity in human liver microsomes using solid-phase extraction
N Hanioka, Y Saito, A Soyama, M Ando… - … of Chromatography B, 2002 - Elsevier
A selective and sensitive assay for amiodarone N-deethylation activity in human liver
microsomes by high-performance liquid chromatography (HPLC) with UV detection is …
microsomes by high-performance liquid chromatography (HPLC) with UV detection is …
Mass spectrometric identification of amiodarone N-monodesethyl metabolite and application of an HPLC method to a pharmacokinetic study
D Marchiset, C Aubert, YC Sumirtapura, A Egre… - European journal of …, 1984 - Springer
Identification of an amiodarone metabolite in the plasma of patients receiving a single dose
of the drμg was carried out by mass-spectrometry following extraction and HPLC separation …
of the drμg was carried out by mass-spectrometry following extraction and HPLC separation …
Simultaneous determination of amiodarone and its major metabolite desethylamiodarone in plasma, urine and tissues by high-performance liquid chromatography
TA Plomp, M Engels, EOR De Medina… - … of Chromatography B …, 1983 - Elsevier
A simple and sensitive high-performance liquid chromatographic method for the
simultaneous assay of amiodarone and desethylarniodarone in plasma, urine and tissues …
simultaneous assay of amiodarone and desethylarniodarone in plasma, urine and tissues …
A rapid HPLC method for the simultaneous determination of amiodarone and its major metabolite in rat plasma and tissues: a useful tool for pharmacokinetic studies
M Rodrigues, G Alves, A Ferreira… - Journal of …, 2013 - academic.oup.com
A rapid and sensitive high-performance liquid chromatography (HPLC) method was
developed and validated in rat plasma and tissue (heart, liver, kidney and lung) …
developed and validated in rat plasma and tissue (heart, liver, kidney and lung) …
High-performance liquid chromatographic assay for amiodarone N-deethylation in microsomes of rat liver
JM Trivier, J Pommery, C Libersa, J Caron… - … of Chromatography B …, 1992 - Elsevier
A reversed-phase high-performance liquid chromatographic assay using ultraviolet
detection is described for determining the production of the major N-dealkylated metabolite …
detection is described for determining the production of the major N-dealkylated metabolite …
A liquid chromatography–mass spectrometry assay method for simultaneous determination of amiodarone and desethylamiodarone in rat specimens
A Shayeganpour, V Somayaji… - Biomedical …, 2007 - Wiley Online Library
A liquid chromatographic‐mass spectrometry (LC/MS) assay method was developed for the
determination of amiodarone and desethylamiodarone in rat specimens. Analytes were …
determination of amiodarone and desethylamiodarone in rat specimens. Analytes were …
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