Chimeric antigen receptor (CAR) T cells are genetically engineered T cells that have been
used to target cancer-associated antigens [1]. The profound success of CAR T cells in …

Investigators developed chimeric antigen receptors (CAR s) for expression on T cells more
than 25 years ago. When the CAR is derived from an antibody, the resultant cell should …

T cells engineered to express Chimeric Antigen Receptors (CARs) induce high rates of
clinical responses in patients with relapsed/refractory hematologic malignancies, and have …

Chimeric antigen receptor (CAR) therapy is a method directing T lymphocytes against
antigens on the surface of tumors, increasing target cell elimination. Genetic engineering …

Chimeric antigen receptor (CAR) T cells are a form of genetically engineered
immunotherapy. This technology uses a patient's own immune effector cells (in this case, T …

Background Chimeric antigen receptor (CAR)-T cells are genetically engineered to
recognize tumor-associated antigens and have potent cytolytic activity against tumors …

Abstract The Chimeric Antigen Receptor (CAR) consists of an antibody-derived targeting
domain fused with T-cell signaling domains that, when expressed by a T-cell, endows the T …

Background Chimeric antigen receptor (CAR) T cells can generate durable clinical
responses in B-cell hematologic malignancies. The effectiveness of this approach led to …

Recent advances in cellular engineering techniques coupled with modern chimeric antigen
receptors (CARs) now permit the efficient targeting and killing of malignant cells using …

Chimeric antigen receptor (CAR) T-cell therapy is a novel therapeutic T-cell engineering
option, where T-cells obtained from a patient's blood are engineered ex vivo to express …