As the non-nuclear initiated effects of steroid hormone signaling have become more widely
accepted, there has been a need to define the novel mechanisms of hormone receptor …

Estradiol and other steroid hormones modulate the nervous system and behavior on both
acute and long-term time scales. Though estradiol was originally characterized as a …

Until recently, the idea that estradiol could affect cellular processes independent of nuclear
estrogen receptors was often dismissed as artifact. This in spite of a large number of …

Estrogen receptors were initially identified as intracellular, ligand-regulated transcription
factors that result in genomic change upon ligand binding. However, rapid estrogen receptor …

It has been over 60years since the first studies have been published describing the effects of
steroid hormones on brain function. For over 30years, estrogen has been presumed to …

Along with its ability to directly regulate gene expression, estradiol influences cell signaling
and brain functions via rapid, membrane-initiated events. In the female rat striatum, estradiol …

Until recently, the idea that oestradiol could affect cellular processes independent of nuclear
oestrogen receptors (ERs) was controversial. This was despite the large number of carefully …

Estrogen receptors were initially identified in the uterus, and later throughout the brain and
body as intracellular, ligand-regulated transcription factors that affect genomic change upon …

Abstract Contribution to Special Issue on Fast effects of steroids. Estrogen receptors α and β
(ERα and ERβ) have a unique relationship with metabotropic glutamate receptors (mGluRs) …

In rats, female sexual behavior is regulated by a well defined limbic–hypothalamic circuit
that integrates sensory and hormonal information. Estradiol activation of this circuit results in …