Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …

Endoplasmic reticulum (ER) stress induces a variety of neuronal cell death pathways that
play a critical role in the pathophysiology of stroke. ER stress occurs when …

Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many
chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate …

The endoplasmic reticulum (ER) is the main cellular organelle involved in protein synthesis,
assembly and secretion. Accumulating evidence shows that across several …

Emerging evidence suggests that the immune and nervous systems are in close interaction
in health and disease conditions. Protein aggregation and proteostasis dysfunction at the …

Neuronal cells are specialists for rapid transfer and translation of information. Their electrical
properties relay on a precise regulation of ion levels while their communication via …

Endoplasmic reticulum (ER) stress plays an important role in a range of neurological
disorders, such as neurodegenation diseases, cerebral ischemia, spinal cord injury …

Under physiological conditions, the endoplasmic reticulum (ER) is a central subcellular
compartment for protein quality control in the secretory pathway that prevents protein …

Besides protein processing, the endoplasmic reticulum (ER) has several other functions
such as lipid synthesis, the transfer of molecules to other cellular compartments, and the …

Astrocytes are glial cells that support neurological function in the central nervous system
(CNS), in part, by providing structural support for neuronal synapses and blood vessels …