Zinc homeostasis is essential for maintaining redox balance, cell proliferation, and
apoptosis. However, excessive zinc exposure is toxic and leads to mitochondrial …

Objective Our aim was to determine if NO prevents mitochondrial oxidant damage by
mobilizing intracellular free zinc (Zn2+). Methods Zn2+ levels were determined by imaging …

Resveratrol (Res) possesses various beneficial effects, including cardioprotective, anti-
inflammatory, anti-aging, and antioxidant properties. However, the precise mechanism …

The Zn 2+ in cardiomyocytes is buffered by structures near T-tubulus and/or sarcoplasmic/
endoplasmic reticulum (S (E) R) while playing roles as either an antioxidant or a toxic agent …

High concentration of zinc has been reported to act as a critical mediator of neuronal death
in the ischemic brain. Our previous studies showed that labile zinc accumulates in …

Zinc plays a role in autophagy and protects cardiac cells from ischemia/reperfusion injury.
This study aimed to test if zinc can induce mitophagy leading to attenuation of mitochondrial …

Zinc plays an important role in cardiomyocytes, where it exists in bound and histochemically
reactive labile Zn2+ forms. Although Zn2+ concentration is under tight control through …

Myocardial zinc dyshomeostasis is associated with caspase-3 activation, ErbB2 degradation
and apoptosis during hypoxia/reoxygenation. Zinc pyrithione replenishes intracellular zinc …

Cadmium, a highly toxic environmental pollutant, is reported to induce toxicity and apoptosis
in multiple organs and cells, all possibly contributing to apoptosis in certain …

Zinc is a highly abundant cation in the brain, essential for cellular functions, including
transcription, enzymatic activity, and cell signaling. However, zinc can also trigger injurious …