Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

For decades, research into memory decline in human cognitive ageing has focused on
neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings …

Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …

The locus coeruleus is connected to the dorsal hippocampus via strong fiber projections. It
becomes activated after arousal and novelty, whereupon noradrenaline is released in the …

The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity
varies considerably across healthy older individuals, and is suggested to contribute to …

Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …

Alzheimer's disease (AD) is the most common cause of cognitive impairment in older
patients, and its prevalence is expected to soar in coming decades. Neuropathologically, AD …

Abnormally phosphorylated tau, an indicator of Alzheimer's disease, accumulates in the first
decades of life in the locus coeruleus (LC), the brain's main noradrenaline supply. However …

Adaptation to the ever-changing world is critical for survival, and our brains are particularly
tuned to remember events that differ from previous experiences. Novel experiences induce …

Leading a mentally stimulating life may build up a reserve of neural and mental resources
that preserve cognitive abilities in late life. Recent autopsy evidence links neuronal density …