The increasing life expectancy has led to a higher incidence of age-related
neurodegenerative conditions. Within this framework, neuroinflammation emerges as a …

Neurodegeneration is characterized by gradual onset and limited availability of specific
biomarkers. Apart from various aetiologies such as infection, trauma, genetic mutation, the …

A precise and dynamic immune response is pivotal for maintaining defense against
pathogens, cellular homeostasis, and tissue repair following injury. Dysregulated immune …

Neuroinflammation refers to a highly complicated reaction of the central nervous system
(CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a …

Disorders of the central nervous system (CNS) have many etiologies compounded by limited
options for treatment. The lack of successful treatments for these disorders stems from the …

Immune dysfunction, a well-established feature of neuroinflammatory disease, is
increasingly recognized in neurodegenerative conditions. Its role is emerging as an early …

Genetically caused neurological disorders of the central nervous system (CNS) are usually
orphan diseases with poor or even fatal clinical outcome and few or no treatments that will …

Accumulating evidence support that chronic innate neuroinflammation mediated by
microglia and astrocytes is a common feature across neurodegenerative disorders …

Chronic inflammation is characterized by longstanding microglial activation followed by
sustained release of inflammatory mediators, which aid in enhanced nitrosative and …

Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous
system (CNS), is the major cause of cognitive and motor dysfunction. While neuronal …