An integrated model for termination of RNA polymerase III transcription

J Xie, U Aiello, Y Clement, N Haidara, M Girbig… - Science …, 2022 - science.org
RNA polymerase III (RNAPIII) synthesizes essential and abundant noncoding RNAs such as
transfer RNAs. Controlling RNAPIII span of activity by accurate and efficient termination is a …

Fail-safe transcription termination: Because one is never enough

JF Lemay, F Bachand - RNA biology, 2015 - Taylor & Francis
Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene
expression that involves the release of the nascent transcript and dissociation of RNAPII …

A bacterial-like mechanism for transcription termination by the Sen1p helicase in budding yeast

O Porrua, D Libri - Nature structural & molecular biology, 2013 - nature.com
Transcription termination is essential to generate functional RNAs and to prevent disruptive
polymerase collisions resulting from concurrent transcription. The yeast Sen1p helicase is …

[PDF][PDF] DNA-directed termination of RNA polymerase II transcription

Z Han, GA Moore, R Mitter, DL Martinez, L Wan… - Molecular cell, 2023 - cell.com
Summary RNA polymerase II (RNAPII) transcription involves initiation from a promoter,
transcriptional elongation through the gene, and termination in the terminator region. In …

Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential

H Vlaming, CA Mimoso, AR Field, BJE Martin… - Nature structural & …, 2022 - nature.com
Precise regulation of transcription by RNA polymerase II (RNAPII) is critical for organismal
growth and development. However, what determines whether an engaged RNAPII will …

Unraveling the mechanistic features of RNA polymerase II termination by the 5′-3′ exoribonuclease Rat1

J Park, M Kang, M Kim - Nucleic acids research, 2015 - academic.oup.com
Within a complex with Rai1, the 5′-3′ exoribonuclease Rat1 promotes termination of RNA
polymerase II (RNAPII) on protein-coding genes, but its underlying molecular mechanism is …

Common mechanism of transcription termination at coding and noncoding RNA genes in fission yeast

M Larochelle, MA Robert, JN Hébert, X Liu… - Nature …, 2018 - nature.com
Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene
expression that is critical for determining the borders between genes. In budding yeast …

Making ends meet: coordination between RNA 3′‐end processing and transcription initiation

PK Andersen, TH Jensen… - Wiley Interdisciplinary …, 2013 - Wiley Online Library
Abstract RNA polymerase II (RNAPII)‐mediated gene transcription initiates at promoters and
ends at terminators. Transcription termination is intimately connected to 3′‐end processing …

[PDF][PDF] Knowing when to stop: transcription termination on protein-coding genes by eukaryotic RNAPII

JB Rodríguez-Molina, S West, LA Passmore - Molecular cell, 2023 - cell.com
Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

Dynamic transitions in RNA polymerase II density profiles during transcription termination

AR Grosso, SF de Almeida, J Braga… - Genome …, 2012 - genome.cshlp.org
Eukaryotic protein-coding genes are transcribed by RNA polymerase II (RNAPII) through a
cycle composed of three main phases: initiation, elongation, and termination. Recent studies …