Pervasive transcription is widespread and needs to be controlled in order to avoid
interference with gene expression. In Saccharomyces cerevisiae, the highly conserved …

Both RNA polymerase I and II (Pol I and Pol II) in budding yeast employ a functionally
homologous “torpedo-like” mechanism to promote transcriptional termination. For two well …

RNA Polymerase II (RNAPII) transcription termination is regulated by the phosphorylation
status of the C-terminal domain (CTD). The phosphatase Rtr1 has been shown to regulate …

RNA polymerase (Pol) III is specialized to transcribe short, abundant RNAs, for which it
terminates transcription on polythymine (dT) stretches on the non-template (NT) strand …

In eukaryotes, RNA polymerase (RNAP) III transcribes hundreds of genes for tRNAs and 5S
rRNA, among others, which share similar promoters and stable transcription initiation …

INTRODUCTION Factor-dependent transcription termination is essential to limit pervasive
transcription, maintain genome stability, balance the expression of neighboring genes, and …

Pervasive transcription is a widespread phenomenon leading to the production of a plethora
of non‐coding RNA s (nc RNA s) without apparent function. Pervasive transcription poses a …

Transcription termination of RNA polymerase II (Pol II) on protein-coding genes in S.
cerevisiae relies on pA site recognition by 3′ end processing factors. Here we demonstrate …

Understanding the mechanism of transcription termination by a eukaryotic RNA polymerase
(RNAP) has been limited by lack of a characterizable intermediate that reflects transition …

Factor-dependent termination uses molecular motors to remodel transcription machineries,
but the associated mechanisms, especially in eukaryotes, are poorly understood. Here we …