Objective To study the association between cytochrome P450 2A6 (CYP2A6) genotype and
metabolism of nicotine to cotinine, identify functional polymorphisms, and develop a …

Aim To investigate whether single-nucleotide polymorphisms (SNPs) in the P450
oxidoreductase (POR) gene were correlated with interindividual variations in cytochrome …

Abstract Background and Aims CYP2B6, a genetically variable enzyme, converts bupropion
to its active metabolite hydroxybupropion. CYP2B6 activity and bupropion‐aided cessation …

Adverse drug reactions (ADRs) are one of the major causes of morbidity and mortality
worldwide. It is well-known that individual genetic make-up is one of the causative factors of …

Sudden death due to acute intoxication occurs frequently in patients with opioid addiction
(OA). To examine whether certain genotypes were associated with this, we examined the …

Smoking continues to be the leading preventable contributor to death worldwide. Twin
studies have suggested a significant genetic contribution underlying most smoking …

Nicotine is the psychoactive substance responsible for tobacco dependence. It is also a
therapeutic used to aid smoking cessation. Cytochrome P450 (CYP) 2A6 is the human …

Introduction Identifying genetic factors associated with smoking cessation could inform
precision cessation interventions. Of major interest is genetic variation in nicotine …

METHODS This partially blind, single-center study randomized (1: 1) 361 participants into
two major groups. In the genetic group (n= 184), CYP2B6 rs2279343 (genotype AA) …

The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has
previously been associated with CYP2A6 activity, response to smoking cessation …