Gliotoxin (1), the infamous representative of the group of epipolythiodioxopiperazines
(ETPs), is a virulence factor of the human pathogenic fungus Aspergillus fumigatus. The …

Gliotoxin is a virulence factor of the human pathogen Aspergillus fumigatus, the leading
cause of invasive aspergillosis. Its toxicity is mediated by the unusual transannular disulfide …

Gliotoxin (1), a virulence factor of the human pathogenic fungus Aspergillus fumigatus, is the
prototype of epipoly (thiodioxopiperazine)(ETP) toxins. Here we report the discovery and …

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that
mediates its toxic effects via redox cycling and is produced by the opportunistic fungal …

Gliotoxin, a redox-active metabolite, is produced by the opportunistic fungal pathogen
Aspergillus fumigatus, and its biosynthesis is directed by the gli gene cluster. Knowledge of …

A broad range of toxic fungal secondary metabolites that have been implicated in human,
animal, and plant diseases share a diketopiperazine scaffold that is overarched by a …

Gliotoxin is a redox-active nonribosomal peptide produced by Aspergillus fumigatus. Like
many other disulfide-containing epipolythiodioxopiperazines, a bis-thiomethylated form is …

Sulfur, the tenth most abundant element in the universe, has been a spearhead in the
development of life on earth. It was not only present in the first organic compounds that …

The fungal metabolite gliotoxin has a redox-active disulfide bridge spanning carbons 3 and
6 of a diketopiperazine (DKP) scaffold. The proposed DKP synthetase, GliP, from Aspergillus …

Mechanistic studies on gliotoxin biosynthesis and self-protection in Aspergillus fumigatus,
both of which require the gliotoxin oxidoreductase GliT, have revealed a rich landscape of …