Rationale Idiopathic pulmonary fibrosis (IPF) is a devasting disease with a worse prognosis
than most cancers. Studies in familial IPF have implicated loss of function mutations in …

Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a fatal form of interstitial lung disease
characterized by enhanced extracellular matrix deposition and AT2 progenitor exhaustion …

Idiopathic pulmonary fibrosis (IPF) is a rare, chronic, and irreversible interstitial lung disease
characterized by progressive destruction of the lung parenchyma and loss of lung function …

Rationale: One of the challenges for the Idiopathic Pulmonary Fibrosis (IPF) field has been
the lack of representative human lung 3D models with progressive fibrosis. Our original …

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease that
leads to respiratory failure and death due to irreversible scarring of the distal lung. While …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …

Pulmonary Fibrosis (PF) has a median survival from diagnosis of 2-4 years. Lung transplant
remains the only cure. Mutations causing shortened telomere length in type II alveolar …

Introduction: Idiopathic pulmonary fibrosis (IPF) is characterised by excessive deposition of
extracellular matrix proteins and destruction of the lung architecture. The aetiology of this …

Rationale: In idiopathic pulmonary fibrosis (IPF) alveolar architecture is disturbed, displaying
fibrotic remodelling, loss of alveolar epithelial cells and the presence of atypical airway …