Due to its favorable chemical properties, zinc is used as a structural or catalytic cofactor in a
very large number of proteins. Despite the apparent abundance of this metal in all cell types …

Zinc is one of the most important metal nutrients for species from all kingdoms, being a key
structural or catalytic component of hundreds of enzymes, crucial for the survival of both …

Zinc is an essential cofactor required for life and, as such, mechanisms exist for its
homeostatic maintenance in biological systems. Despite the evolutionary distance between …

Zinc ion (Zn2+) is an essential cofactor required by numerous metalloenzymes and is
important for structural and regulatory systems in bacterial cells. Zn2+ is a trace element …

As a structural, catalytic, and signaling component, zinc is necessary for the growth and
development of plants, animals, and microorganisms. Zinc is also essential for the growth of …

The ability of a large number of bacterial pathogens to multiply in the infected host and
cause disease is dependent on their ability to express high affinity zinc importers. In many …

Innate immune cells such as macrophages and neutrophils initiate protective inflammatory
responses and engage antimicrobial responses to provide frontline defence against …

Background Zinc is an essential element for all living cells. Recent studies have shown that
the ZnuABC zinc uptake system significantly contributes to the ability of several pathogens to …

Recent studies on pathogenic streptococci have revealed that zinc is a pivotal metal ion in
their interaction with the host. In these streptococci, systems exist that ensure optimal use of …

To investigate the relevance of zinc in host-pathogen interactions, we have constructed
Salmonella enterica mutant strains in which the znuA gene, which encodes the periplasmic …