Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Inflammation: a novel therapeutic target/direction in atherosclerosis

B Li, W Li, X Li, H Zhou - Current Pharmaceutical Design, 2017 - ingentaconnect.com
Over the past two decades, the viewpoint of atherosclerosis has been replaced gradually by
a lipiddriven, chronic, low-grade inflammatory disease of the arterial wall. Current treatment …

The biological role of inflammation in atherosclerosis

BW Wong, A Meredith, D Lin, BM McManus - Canadian Journal of …, 2012 - Elsevier
The concept of the involvement of inflammation in the pathogenesis of atherosclerosis has
existed since the 1800s, stemming from sentinel pathologic observations made by Rudolf …

Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease

G Fredman, CN Serhan - Nature Reviews Cardiology, 2024 - nature.com
Timely resolution of the acute inflammatory response (or inflammation resolution) is an
active, highly coordinated process that is essential to optimal health. Inflammation resolution …

Inflammation in atherosclerosis: from pathophysiology to practice

P Libby, PM Ridker, GK Hansson… - Journal of the American …, 2009 - jacc.org
Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …

Inflammation and coronary artery disease

AY Tiong, D Brieger - American heart journal, 2005 - Elsevier
Inflammation is now recognized as being pivotal in the pathogenesis of atherosclerosis. This
review highlights key concepts in our current understanding of the role of inflammation in the …

Atherosclerosis and inflammation: overview and updates

GR Geovanini, P Libby - Clinical science, 2018 - portlandpress.com
The concept that inflammation participates pivotally in the pathogenesis of atherosclerosis
and its complications has gained considerable attention, but has not yet entered clinical …

Inflammation as a therapeutic target in atherosclerosis

MT Nguyen, S Fernando, N Schwarz, JTM Tan… - Journal of clinical …, 2019 - mdpi.com
Atherosclerotic coronary artery disease (CAD) results from build-up of cholesterol-rich
plaques in the walls of the coronary arteries and is a leading cause of death. Inflammation is …

Anti-inflammatory therapeutics for the treatment of atherosclerosis

IF Charo, R Taub - Nature reviews Drug discovery, 2011 - nature.com
Atherosclerosis is the primary cause of heart disease and stroke and is thus the underlying
pathology of the leading causes of death in the western world. Although risk can be reduced …