Organoid and spheroid tumor models: techniques and applications
S Gunti, ATK Hoke, KP Vu, NR London Jr - Cancers, 2021 - mdpi.com
Simple Summary Cell cultures can be carried out in three dimensions (3D). Organoids and
spheroids are different 3D cell culture models that can be cultured with different techniques …
spheroids are different 3D cell culture models that can be cultured with different techniques …
Promising applications of tumor spheroids and organoids for personalized medicine
Simple Summary Presently, the investigation of the tumor is carried out using different
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …
Organoids in cancer research
J Drost, H Clevers - Nature Reviews Cancer, 2018 - nature.com
The recent advances in in vitro 3D culture technologies, such as organoids, have opened
new avenues for the development of novel, more physiological human cancer models. Such …
new avenues for the development of novel, more physiological human cancer models. Such …
Flourishing tumor organoids: History, emerging technology, and application
Q Yang, M Li, X Yang, Z Xiao, X Tong… - Bioengineering & …, 2023 - Wiley Online Library
Malignant tumors are one of the leading causes of death which impose an increasingly
heavy burden on all countries. Therefore, the establishment of research models that closely …
heavy burden on all countries. Therefore, the establishment of research models that closely …
Organoids: An intermediate modeling platform in precision oncology
Cancer harbors variable heterogeneity and plasticity. Thus far, our comprehension is greatly
based on cell lines, organoids, and patient-derived tumor xenografts (PDTXs). Organoids …
based on cell lines, organoids, and patient-derived tumor xenografts (PDTXs). Organoids …
Standardization of organoid culture in cancer research
C Zhou, Y Wu, Z Wang, Y Liu, J Yu, W Wang… - Cancer …, 2023 - Wiley Online Library
Establishing a valid in vitro model to represent tumor heterogeneity and biology is critical but
challenging. Tumor organoids are self‐assembled three‐dimensional cell clusters which are …
challenging. Tumor organoids are self‐assembled three‐dimensional cell clusters which are …
Tumor organoids: applications in cancer modeling and potentials in precision medicine
H Xu, D Jiao, A Liu, K Wu - Journal of hematology & oncology, 2022 - Springer
Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor
heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors …
heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors …
Concise review: current status of three-dimensional organoids as preclinical models
Abstract Three-dimensional (3D) cultures use the property of some cells to self-organize in
matrices and generate structures that can be programmed to represent an organ or a …
matrices and generate structures that can be programmed to represent an organ or a …
Organoid models for cancer research
H Clevers, DA Tuveson - Annual Review of Cancer Biology, 2019 - annualreviews.org
Organoid cultures have emerged as powerful model systems accelerating discoveries in
cellular and cancer biology. These three-dimensional cultures are amenable to diverse …
cellular and cancer biology. These three-dimensional cultures are amenable to diverse …
Three-dimensional in vitro tumor spheroid models for evaluation of anticancer therapy: recent updates
Simple Summary Cancer is a global public health issue. The development and use of in vitro
cellular models with pre-clinical animal models are essential to elucidate the complex …
cellular models with pre-clinical animal models are essential to elucidate the complex …