The RNA recognition motif, a plastic RNA‐binding platform to regulate post‐transcriptional gene expression

C Maris, C Dominguez, FHT Allain - The FEBS journal, 2005 - Wiley Online Library
The RNA recognition motif (RRM), also known as RNA‐binding domain (RBD) or
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …

[HTML][HTML] Temporal translational control by a metastable RNA structure

J Møller-Jensen, T Franch, K Gerdes - Journal of Biological Chemistry, 2001 - ASBMB
Programmed cell death by thehok/sok locus of plasmid R1 relies on a complex translational
control mechanism. The highly stablehok mRNA is activated by 3′-end exonucleolytical …

[HTML][HTML] The grand challenge of characterizing ribonucleoprotein networks

GG Tartaglia - Frontiers in molecular biosciences, 2016 - frontiersin.org
Protein–RNA interactions are at the heart of cell regulation. From transcription, processing,
storage, and translation, all the stages in the life cycle of an RNA depend on interactions …

[HTML][HTML] Compendium of methods to uncover RNA-protein interactions in vivo

M Majumder, V Palanisamy - Methods and Protocols, 2021 - mdpi.com
Control of gene expression is critical in shaping the pro-and eukaryotic organisms' genotype
and phenotype. The gene expression regulatory pathways solely rely on protein–protein …

An atlas of posttranslational modifications on RNA binding proteins

WE England, J Wang, S Chen, P Baldi… - Nucleic acids …, 2022 - academic.oup.com
RNA structure and function are intimately tied to RNA binding protein recognition and
regulation. Posttranslational modifications are chemical modifications which can control …

ATtRACT—a database of RNA-binding proteins and associated motifs

G Giudice, F Sánchez-Cabo, C Torroja… - Database, 2016 - academic.oup.com
RNA-binding proteins (RBPs) play a crucial role in key cellular processes, including RNA
transport, splicing, polyadenylation and stability. Understanding the interaction between …

[HTML][HTML] Protein kinase A stimulates binding of multiple proteins to a U-rich domain in the 3′-untranslated region of lactate dehydrogenase A mRNA that is required …

D Tian, D Huang, RC Brown, RA Jungmann - Journal of Biological …, 1998 - ASBMB
We have explored the molecular basis of the cAMP-induced stabilization of lactate
dehydrogenase A (LDH-A) mRNA and identified four cytoplasmic proteins of 96, 67, 52, and …

From parts lists to functional significance—RNA–protein interactions in gene regulation

C Kilchert, K Sträßer, V Kunetsky… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Hundreds of canonical RNA binding proteins facilitate diverse and essential RNA
processing steps in cells forming a central regulatory point in gene expression. However …

Modeling the binding specificity of the RNA-binding protein GLD-1 suggests a function of coding region–located sites in translational repression

A Brümmer, S Kishore, D Subasic, M Hengartner… - Rna, 2013 - rnajournal.cshlp.org
To understand the function of the hundreds of RNA-binding proteins (RBPs) that are
encoded in animal genomes it is important to identify their target RNAs. Although it is …

Hypoxia and hypoglycemia synergistically regulate mRNA stability

KR Carraway, EM Johnson, TC Kauffmann, NJ Fry… - RNA biology, 2017 - Taylor & Francis
Ischemic events, common in many diseases, result from decreased blood flow and impaired
delivery of oxygen and glucose to tissues of the body. While much is known about the …