Although aggressive pituitary adenomas (PAs) have been proposed and widely discussed
for more than a decade, there is no general agreement regarding their definition, diagnosis …

Refractory pituitary adenomas (PAs) are defined as aggressive-invasive PAs characterized
by a high Ki-67 index, rapid growth, frequent recurrence, and resistance to conventional …

Background Most of pituitary adenomas (PAs) are slow-growing benign tumors which can
be cured or controlled by conventional therapies, including surgery, medical treatment or …

Refractory pituitary adenomas (PAs) are defined as aggressive-invasive PAs characterized
by rapid growth, frequent recurrence, a high Ki-67 index, and resistance to standard …

Pituitary adenomas are classified as typical or atypical, invasive or noninvasive, and
aggressive or nonaggressive based on pathological features, radiological findings, and …

The rare aggressive pituitary adenoma presents a special challenge, due to the
heterogenous presentation of the disease. The prognosis of aggressive pituitary adenomas …

Background Pituitary carcinomas (PC) and atypical pituitary adenomas (APA) are rare
variants of pituitary tumors for which no evidence-based treatment currently exists. We …

With a prevalence of 80–100/100000, pituitary adenomas are more frequent than thought.
The rare aggressive pituitary adenoma presents a special challenge, due to the …

Management of aggressive pituitary adenomas is challenging due to a paucity of rigorous
evidence supporting available treatment approaches. Recent guidelines emphasize the …

The WHO categorizes pituitary tumours as typical adenomas, atypical adenomas and
pituitary carcinomas, with typical adenomas constituting the major class. However, the WHO …