Use of a procalcitonin-guided antibiotic treatment algorithm in the pediatric intensive care unit

SE Katz, J Crook, J Gillon, JE Stanford… - The Pediatric …, 2021 - journals.lww.com
Background: The utility of procalcitonin testing in the pediatric intensive care unit (PICU) is
not known. We sought to determine the impact of a procalcitonin-guided antibiotic treatment …

Procalcitonin‐guided antibiotic therapy: a systematic review and meta‐analysis

NJ Soni, DJ Samson, JL Galaydick… - Journal of hospital …, 2013 - Wiley Online Library
BACKGROUND The utility of procalcitonin to manage patients with infections is unclear. A
systematic review of comparative studies using procalcitonin‐guided antibiotic therapy in …

Compliance with procalcitonin algorithm antibiotic recommendations for patients in medical intensive care unit

AA Ammar, SW Lam, A Duggal… - … : The Journal of …, 2017 - Wiley Online Library
Study Objectives To describe compliance with antibiotic recommendations based on a
previously published procalcitonin (PCT)‐guided algorithm in clinical practice, to compare …

Promise and limitations of procalcitonin to identify bacterial infections in the pediatric intensive care unit

O Ramilo, R Rodriguez-Fernandez, A Mejias - The Journal of Pediatrics, 2016 - jpeds.com
Differentiating between bacterial and viral infections to decide when to initiate—or stop—
antibiotic therapy in a child with an acute febrile illness continues to represent a challenging …

Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials

P Kopterides, II Siempos, I Tsangaris… - Critical care …, 2010 - journals.lww.com
Objective: There is increasing interest for strategies that could curtail antibiotic resistance in
the critical care setting. We sought to determine the effectiveness and safety of procalcitonin …

Low sensitivity of procalcitonin for bacteremia at an academic medical center: a cautionary tale for antimicrobial stewardship

KJ Goodlet, EA Cameron… - Open Forum Infectious …, 2020 - academic.oup.com
Background Procalcitonin testing has been adopted by antimicrobial stewardship programs
as a means of reducing inappropriate antibiotic use, including within intensive care units …

Procalcitonin to detect suspected bacterial infections in the PICU

IM Mandell, S Aghamohammadi… - Pediatric Critical Care …, 2016 - journals.lww.com
Objectives: Nonspecific clinical symptoms frequently lead to suspicion of bacterial infection
in critically ill children. Clinicians send bacterial cultures for suspected infection and begin …

Effect of the procalcitonin assay on antibiotic use in critically ill children

RK Ross, L Keele, S Kubis, AJ Lautz… - Journal of the …, 2018 - academic.oup.com
We retrospectively studied the effect of introducing procalcitonin into clinical practice on
antibiotic use within a large academic pediatric intensive care unit. In the absence of a …

Procalcitonin-guidance reduces antibiotic exposure in children with nosocomial infection (PRORANI)

C Launes, E Esteban, M Balaguer, M Alsina… - Journal of …, 2016 - journalofinfection.com
Procalcitonin (PCT) is one of the best blood biomarkers of bacterial infection, with results
published elsewhere showing its high sensitivity and specificity for both invasive and …

A real-world assessment of procalcitonin combined with antimicrobial stewardship in a community ICU

BJ Langford, D Beriault, KL Schwartz, J Seah… - Journal of Critical …, 2020 - Elsevier
Purpose We evaluated the feasibility and impact of PCT-guided antibiotic duration combined
with an established antibiotic stewardship program (ASP) in a community hospital intensive …