Programming cell–cell communications with engineered cell origami clusters

Z Ge, J Liu, L Guo, G Yao, Q Li, L Wang… - Journal of the …, 2020 - ACS Publications
Cells existing in the form of clusters often exhibit distinct physiological functions from their
monodispersed forms, which have a close association with tissue and organ development …

DNA origami signaling units transduce chemical and mechanical signals in synthetic cells

K Jahnke, M Illig, M Scheffold, MP Tran… - Advanced Functional …, 2024 - Wiley Online Library
Transmembrane proteins transmit chemical signals as well as mechanical cues. The latter is
often achieved by coupling to the cytoskeleton. The incorporation of fully engineerable …

Engineering cell surface function with DNA origami

E Akbari, MY Mollica, CR Lucas… - Advanced …, 2017 - Wiley Online Library
A specific and reversible method is reported to engineer cell‐membrane function by
embedding DNA‐origami nanodevices onto the cell surface. Robust membrane …

Modular DNA-origami-based nanoarrays enhance cell binding affinity through the “lock-and-key” interaction

M Mao, Z Lin, L Chen, Z Zou, J Zhang… - Journal of the …, 2023 - ACS Publications
Surface proteins of cells are generally recognized through receptor–ligand interactions
(RLIs) in disease diagnosis, but their nonuniform spatial distribution and higher-order …

DNA origami: folded DNA‐nanodevices that can direct and interpret cell behavior

CJ Kearney, CR Lucas, FJ O'Brien… - Advanced …, 2016 - Wiley Online Library
DNA origami is a DNA‐based nanotechnology that utilizes programmed combinations of
short complementary oligonucleotides to fold a large single strand of DNA into precise 2D …

Fabricating higher-order functional DNA origami structures to reveal biological processes at multiple scales

Y Zhou, J Dong, Q Wang - NPG Asia Materials, 2023 - nature.com
DNA origami technology enables the precise assembly of well-defined two-dimensional and
three-dimensional nanostructures with DNA, an inherently biocompatible material. Given …

DNA origami nanostructures elicit dose‐dependent immunogenicity and are nontoxic up to high doses In vivo

CR Lucas, PD Halley, AA Chowdury, BK Harrington… - Small, 2022 - Wiley Online Library
DNA origami (DO) nanotechnology enables the construction of precise nanostructures
capable of functionalization with small molecule drugs, nucleic acids, and proteins …

Visualization of the cellular uptake and trafficking of DNA origami nanostructures in cancer cells

P Wang, MA Rahman, Z Zhao, K Weiss… - Journal of the …, 2018 - ACS Publications
DNA origami is a promising molecular delivery system for a variety of therapeutic
applications including cancer therapy, given its capability to fabricate homogeneous …

Multiscale origami structures as interface for cells

A Angelin, S Weigel, R Garrecht… - Angewandte Chemie …, 2015 - Wiley Online Library
A DNA‐based platform was developed to address fundamental aspects of early stages of
cell signaling in living cells. By site‐directed sorting of differently encoded, protein …

Functional DNA-based cytoskeletons for synthetic cells

P Zhan, K Jahnke, N Liu, K Göpfrich - Nature chemistry, 2022 - nature.com
The cytoskeleton is an essential component of a cell. It controls the cell shape, establishes
the internal organization, and performs vital biological functions. Building synthetic …