Neuronal complexity is attenuated in chronic migraine and restored by HDAC6 inhibition
Z Bertels, H Singh, I Dripps, K Siegersma, AF Tipton… - bioRxiv, 2020 - biorxiv.org
Migraine is the third most prevalent disease worldwide but the mechanisms that underlie
migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal …
migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal …
[HTML][HTML] Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition
Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie
migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal …
migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal …
Astrocyte dysfunction increases cortical dendritic excitability and promotes cranial pain in familial migraine
J Romanos, D Benke, D Pietrobon, HU Zeilhofer… - Science …, 2020 - science.org
Astrocytes are essential contributors to neuronal function. As a consequence, disturbed
astrocyte-neuron interactions are involved in the pathophysiology of several neurological …
astrocyte-neuron interactions are involved in the pathophysiology of several neurological …
[HTML][HTML] Cortical spreading depression causes unique dysregulation of inflammatory pathways in a transgenic mouse model of migraine
Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with
aura caused by mutations in CACNA1A that encodes the α 1A subunit of voltage-gated Ca V …
aura caused by mutations in CACNA1A that encodes the α 1A subunit of voltage-gated Ca V …
[HTML][HTML] Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in CaV2. 1 knockin migraine mice
A Tottene, R Conti, A Fabbro, D Vecchia… - Neuron, 2009 - cell.com
Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial
hemiplegic migraine type 1: FHM1) is caused by mutations in Ca V 2.1 (P/Q-type) Ca 2+ …
hemiplegic migraine type 1: FHM1) is caused by mutations in Ca V 2.1 (P/Q-type) Ca 2+ …
Cortical spreading depression and familial hemiplegic migraine 2015
D Pietrobon - The journal of headache and pain, 2015 - Springer
The molecular and cellular mechanisms of the primary brain dysfunction leading to the onset
of a migraine attack and to susceptibility to cortical spreading depression (CSD), the …
of a migraine attack and to susceptibility to cortical spreading depression (CSD), the …
Abnormal synaptic Ca2+ homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice
K Eikermann‐Haerter, M Arbel‐Ornath… - Annals of …, 2015 - Wiley Online Library
Objective Migraine is among the most common and debilitating neurological conditions.
Familial hemiplegic migraine type 1 (FHM1), a monogenic migraine subtype, is caused by …
Familial hemiplegic migraine type 1 (FHM1), a monogenic migraine subtype, is caused by …
[HTML][HTML] Deciphering migraine
T Takano, M Nedergaard - The Journal of clinical …, 2009 - Am Soc Clin Investig
Migraine is an episodic headache disorder affecting as many as 10% of people worldwide.
Familial hemiplegic migraine (FHM) is an autosomal dominant subtype of severe migraine …
Familial hemiplegic migraine (FHM) is an autosomal dominant subtype of severe migraine …
Mapping migraine to a common brain network
Inconsistent findings from migraine neuroimaging studies have limited attempts to localize
migraine symptomatology. Novel brain network mapping techniques offer a new approach …
migraine symptomatology. Novel brain network mapping techniques offer a new approach …
Structural connectome changes in episodic migraine: the role of the cerebellum
BACKGROUND: Migraine's pathophysiology remains poorly understood, yet a growing
number of studies have shown structural connectivity disruptions across large-scale brain …
number of studies have shown structural connectivity disruptions across large-scale brain …