Neuronal complexity is attenuated in chronic migraine and restored by HDAC6 inhibition

Z Bertels, H Singh, I Dripps, K Siegersma, AF Tipton… - bioRxiv, 2020 - biorxiv.org
Migraine is the third most prevalent disease worldwide but the mechanisms that underlie
migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal …

[HTML][HTML] Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition

Z Bertels, H Singh, I Dripps, K Siegersma, AF Tipton… - Elife, 2021 - elifesciences.org
Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie
migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal …

Astrocyte dysfunction increases cortical dendritic excitability and promotes cranial pain in familial migraine

J Romanos, D Benke, D Pietrobon, HU Zeilhofer… - Science …, 2020 - science.org
Astrocytes are essential contributors to neuronal function. As a consequence, disturbed
astrocyte-neuron interactions are involved in the pathophysiology of several neurological …

[HTML][HTML] Cortical spreading depression causes unique dysregulation of inflammatory pathways in a transgenic mouse model of migraine

E Eising, R Shyti, PAC 't Hoen, LS Vijfhuizen… - Molecular …, 2017 - Springer
Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with
aura caused by mutations in CACNA1A that encodes the α 1A subunit of voltage-gated Ca V …

[HTML][HTML] Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in CaV2. 1 knockin migraine mice

A Tottene, R Conti, A Fabbro, D Vecchia… - Neuron, 2009 - cell.com
Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial
hemiplegic migraine type 1: FHM1) is caused by mutations in Ca V 2.1 (P/Q-type) Ca 2+ …

Cortical spreading depression and familial hemiplegic migraine 2015

D Pietrobon - The journal of headache and pain, 2015 - Springer
The molecular and cellular mechanisms of the primary brain dysfunction leading to the onset
of a migraine attack and to susceptibility to cortical spreading depression (CSD), the …

Abnormal synaptic Ca2+ homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice

K Eikermann‐Haerter, M Arbel‐Ornath… - Annals of …, 2015 - Wiley Online Library
Objective Migraine is among the most common and debilitating neurological conditions.
Familial hemiplegic migraine type 1 (FHM1), a monogenic migraine subtype, is caused by …

[HTML][HTML] Deciphering migraine

T Takano, M Nedergaard - The Journal of clinical …, 2009 - Am Soc Clin Investig
Migraine is an episodic headache disorder affecting as many as 10% of people worldwide.
Familial hemiplegic migraine (FHM) is an autosomal dominant subtype of severe migraine …

Mapping migraine to a common brain network

MJ Burke, J Joutsa, AL Cohen, L Soussand, D Cooke… - Brain, 2020 - academic.oup.com
Inconsistent findings from migraine neuroimaging studies have limited attempts to localize
migraine symptomatology. Novel brain network mapping techniques offer a new approach …

Structural connectome changes in episodic migraine: the role of the cerebellum

A Matoso, AR Fouto, I Esteves, A Ruiz-Tagle… - bioRxiv, 2024 - biorxiv.org
BACKGROUND: Migraine's pathophysiology remains poorly understood, yet a growing
number of studies have shown structural connectivity disruptions across large-scale brain …