[HTML][HTML] Advanced combination treatment with biologic agents and novel small molecule drugs for inflammatory bowel disease

V Solitano, C Ma, J Hanžel, R Panaccione… - Gastroenterology & …, 2023 - ncbi.nlm.nih.gov
The use of combination therapy with a biologic agent and immunosuppressant has well-
established efficacy and safety and is common practice in the management of inflammatory …

[HTML][HTML] Back to the drawing board: Overview of the next generation of combination therapy for inflammatory bowel disease

JA Lowell, MJ Farber, K Sultan - World Journal of Gastroenterology, 2024 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is entering a potentially new era of combined
therapeutics. Triantafillidis et al provide an insightful review of the current state of …

Combining biologics in inflammatory bowel disease and other immune mediated inflammatory disorders

RP Hirten, M Iacucci, S Shah, S Ghosh… - Clinical Gastroenterology …, 2018 - Elsevier
Current therapies used in the treatment of inflammatory bowel disease (IBD) are not effective
in all patients. Biologic agents result in approximately 40% remission rates at 1 year in …

Dual biologic or small molecule therapy for treatment of inflammatory bowel disease: a systematic review and meta-analysis

W Ahmed, J Galati, A Kumar, PJ Christos… - Clinical …, 2022 - Elsevier
Background and Aims We conducted a systematic review and meta-analysis to summarize
emerging data on the safety and effectiveness of dual biologic therapy in combination or …

Current evidence for combined targeted therapy for the treatment of inflammatory bowel disease

P Wetwittayakhlang, PL Lakatos - Journal of the Canadian …, 2024 - academic.oup.com
Biologicals and small molecules have revolutionized the medical management of
inflammatory bowel diseases (IBD), yet they are only effective in a proportion of patients, and …

Combination therapy in inflammatory bowel disease: Current evidence and perspectives

C Dai, YH Huang, M Jiang - International Immunopharmacology, 2023 - Elsevier
Abstract Background and Objective Inflammatory Bowel Diseases (IBD) are chronic
nonspecific intestinal inflammatory diseases with a relapsing-remitting course, including …

[HTML][HTML] Role of the combination of biologics and/or small molecules in the treatment of patients with inflammatory bowel disease

D Balderramo - World Journal of Gastroenterology, 2022 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a group of chronic diseases that includes ulcerative
colitis, Crohn's disease, and indeterminate colitis. Patients with IBD require prolonged …

The use of combination biological or small molecule therapy in inflammatory bowel disease: a retrospective cohort study

K Glassner, A Oglat, A Duran, P Koduru… - Journal of Digestive …, 2020 - Wiley Online Library
Objective There are limited data on using more than one biologic or small molecule drug
combined to treat patients with inflammatory bowel disease. The aim of our study was to …

[HTML][HTML] Current status of novel biologics and small molecule drugs in the individualized treatment of inflammatory bowel disease

YH Xu, WM Zhu, Z Guo - World Journal of Gastroenterology, 2022 - ncbi.nlm.nih.gov
Abstract Treatment strategies for inflammatory bowel disease (IBD) are rapidly evolving with
the development of biologics and small molecule drugs (SMDs). However, these drugs are …

The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment)

S Danese, V Solitano, V Jairath, L Peyrin-Biroulet - Gut, 2022 - gut.bmj.com
The expanding therapeutic armamentarium available for inflammatory bowel disease (IBD)
as well as multiple compounds in clinical development inevitably raises questions as to their …