As the vital organelles for cell energy metabolism, mitochondria are essential for oocyte
maturation, fertilization, and embryo development. Abnormalities in quantity, quality, and …

Mitochondria, known as the energy factories in all cells, are key regulators of multiple vital
cellular processes and affect all aspects of mammalian reproduction, being essential for …

Mitochondria transfer techniques were first designed to prevent the transmission of diseases
due to mutations in mtDNA, as these organelles are exclusively transmitted to the offspring …

Oocyte quality is one of the most important factors involving in female reproduction. The
number of compromised oocytes will increase with maternal age, while mitochondrial …

Poor ovarian responders exhibit a quantitative reduction in their follicular pool, and most
cases are also associated with poor oocyte quality due to patient's age, which leads to …

Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

Mitochondrial dysfunction is implicated in disease and age-related infertility. Mitochondrial
replacement therapies (MRT) in oocytes or zygotes, such as pronuclear (PNT), spindle (ST) …

Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte
quality which is important for fertilization and development into viable offspring. Quality …

Along with the decline in oocyte quality, numerous defects such as mitochondrial
insufficiency and the increase of mutation and deletion have been reported in oocyte …

Older women are often the most challenging group of patients in fertility clinics due to a
decline in both number and overall quality of oocytes. The quality of oocytes has been linked …