Mitochondrial supplementation was proposed as a complementary treatment to assisted
reproductive technologies to improve oocyte competence and support post-fertilization …

Mitochondrial dysfunction is widely implicated in various human diseases, through
mechanisms that go beyond mitochondria's well-established role in energy generation …

Ovarian aging is characterized by a decline in both the total number and overall quality of
oocytes, the latter of which has been experimentally tied to mitochondrial dysfunction …

In addition to their role in generating energy (ATP), other possible regulatory functions for
mitochondria in the mature oocyte, preimplantation stage embryo and differentiating …

The use of mitochondrial transfer as a clinic procedure is drawing closer to reality. Here we
provide a detailed overview of mitochondrial transfer techniques–both established and …

Mitochondrial biology plays an important role in the reproductive process, with influence on
germ cell development and quality as well as embryonic development and reproductive …

Mitochondria are the key regulators of multiple vital cellular processes, including apoptosis,
calcium homeostasis, and the generation of ATP via the metabolic pathway known as …

Background: Mitochondrial dysfunction has been suggested as a major cause of age-
induced decline in oocyte quality. In the past, donor oocyte cytoplasmic transfer showed …

Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …

Mitochondrial production of cellular energy is essential to oocyte function, zygote
development and successful continuation of pregnancy. This review focuses on several key …