Limitations in the current therapeutic strategies for the prevention of progression of chronic
kidney disease (CKD) to end stage renal disease has been a drawback to improving patient …

With limited therapeutic intervention in preventing the progression to end-stage renal
disease, chronic kidney disease (CKD) remains a global health-care burden. Aristolochic …

Chronic aristolochic acid (AA) nephropathy (CAAN) caused by intake of AA-containing herbs
is difficult to treat. We evaluated the therapeutic effect of bone marrow (BM) mesenchymal …

Human liver stem-cell-derived extracellular vesicles (HLSC-EVs) exhibit therapeutic
properties in various pre-clinical models of kidney injury. We previously reported an overall …

Aristolochic acid nephropathy (AAN) is a progressive kidney disease caused by some
herbal medicines, but treatment remains ineffective. We previously found that leucine-rich α …

Background: Genetically modified mice are used to investigate disease and assess potential
interventions. However, research into kidney fibrosis is hampered by a lack of models of …

Background/Aim: Aristolochic acid (AA) nephropathy, first reported as Chinese herbs
nephropathy, is a rapidly progressive tubulointerstitial nephropathy that results in severe …

Acute and chronic kidney injuries are multifactorial traits that involve various risk factors.
Experimental animal models are crucial to unravel important aspects of injury and its …

Aristolochic acid (AA) is the causative nephrotoxic alkaloid in AA nephropathy, which results
in a tubulointerstitial fibrosis. AA causes direct proximal tubule damage as well as an influx …

Aristolochic acid nephropathy (AAN) is a progressive tubulointerstitial nephritis caused by
the intake of aristolochic acids (AA) contained in Chinese herbal remedies or contaminated …