Caloric restriction has consistently been shown to extend life span and ameliorate aging-
related diseases. These effects may be due to diet-induced reactive oxygen species acting …

Intermittent fasting (IF) regimens have gained considerable popularity in recent years, as
some people find these diets easier to follow than traditional calorie restriction (CR) …

Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in
which no or few calories are consumed for time periods that can range from 12 hours to …

Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

To date, the only intervention that has consistently been shown to slow the rate of aging, and
to increase mean and maximum lifespan in short-lived species, is life-long calorie restriction …

Background Although preliminary evidence suggests that intermittent calorie restriction
(ICR) exerts stronger effects on metabolic parameters, which may link obesity and major …

Caloric restriction (CR) is the only experimental nongenetic paradigm known to increase
lifespan. It has broad applicability and extends the life of most species through a retardation …

Background Altering the temporal distribution of energy intake (EI) and introducing periods
of intermittent fasting (IF) exert important metabolic effects. Restricting EI to earlier in the day …

Background Metabolic and behavioral adaptations to caloric restriction (CR) in free-living
conditions have not yet been objectively measured. Methodology and Principal Findings …

Background Caloric restriction (CR) has long been recognized as a dietary therapy that
improves health and increases longevity. Little is known about the persistent effects of CR …