The ATP-binding cassette transporters (ABC transporters) are one of the oldest and largest
gene families. In humans, this superfamily comprises 48 ABC transporters divided into …

The ATP-binding cassette transporters (ABC transporters) are one of the oldest and largest
gene families. In humans, this superfamily comprises 48 ABC transporters divided into …

ABC transporters play essential roles of detoxification and selective transport of substances
in humans. ABCG2 is a half-transporter mainly expressed at the plasma membrane in many …

Human organs have to be protected from a myriad of xenobiotic compounds. One of the
mechanisms mitigating the toxic effects of drugs is to actively extrude them from the cell. ATP …

The human ATP-binding cassette B5 (ABCB5) transporter, a member of the ABC transporter
superfamily, is linked to chemoresistance in tumour cells by drug effluxion. However, little is …

Although overexpression of multiple ATP-binding cassette transporters has been reported in
clinical samples, few studies have examined how coexpression of multiple transporters …

Background: ABCB1 is a key ABC efflux transporter modulating the pharmacokinetics of a
large percentage of drugs. ABCB1 is also a site of transporter mediated drug-drug …

ABC transporters constitute one of the largest gene families among all species [1–3].
Although many of these transporters have been discovered in other species (for instance …

ATP-binding cassette (ABC) transporters are one of the largest families of membrane
proteins and are ATP-driven transport systems, which are found universally in all pro-and …

ABC‐type drug efflux pumps, eg, ABCB1 (= P‐glycoprotein,= MDR1), ABCC1 (= MRP1), and
ABCG2 (= MXR,= BCRP), confer a multi‐drug resistance (MDR) phenotype to cancer cells …