[HTML][HTML] CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

S Sanchez-Roige, MV Jennings, HHA Thorpe… - Translational …, 2023 - nature.com
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to
act prematurely and is associated with multiple forms of psychopathology, including …

Genome-wide association studies of impulsive personality traits (BIS-11 and UPPS-P) and drug experimentation in up to 22,861 adult research participants identify …

S Sanchez-Roige, P Fontanillas, SL Elson… - Journal of …, 2019 - Soc Neuroscience
Impulsive personality traits are complex heritable traits that are governed by frontal-
subcortical circuits and are associated with numerous neuropsychiatric disorders …

Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation

JC Gray, J MacKillop, J Weafer, KM Hernandez… - Psychiatry …, 2018 - Elsevier
Impulsive personality traits are heritable risk factors and putative endophenotypes for
addiction and other psychiatric disorders involving disinhibition. This study examined the …

Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: implications for impulsivity

E Congdon, KP Lesch, T Canli - American Journal of Medical …, 2008 - Wiley Online Library
Impulsivity, a highly prevalent symptom in multiple psychiatric disorders, is a partially
heritable trait influenced by specific biological mechanisms. In particular, dopamine is …

The latent genetic structure of impulsivity and its relation to internalizing psychopathology

DE Gustavson, NP Friedman… - Psychological …, 2020 - journals.sagepub.com
Factor analyses suggest that impulsivity traits that capture tendencies to act prematurely or
take risks tap partially distinct constructs. We applied genomic structure equation modeling …

[HTML][HTML] Genetic variation in CADM2 as a link between psychological traits and obesity

J Morris, MES Bailey, D Baldassarre, B Cullen… - Scientific Reports, 2019 - nature.com
CADM2 has been associated with a range of behavioural and metabolic traits, including
physical activity, risk-taking, educational attainment, alcohol and cannabis use and obesity …

[HTML][HTML] Corticolimbic DCC gene co-expression networks as predictors of impulsivity in children

JM Restrepo-Lozano, I Pokhvisneva, Z Wang… - Molecular …, 2022 - nature.com
Inhibitory control deficits are prevalent in multiple neuropsychiatric conditions. The
communication-as well as the connectivity-between corticolimbic regions of the brain are …

[PDF][PDF] Replication and characterization of CADM2 and MSRA genes on human behavior

B Boutwell, D Hinds, M Agee, B Alipanahi, A Auton… - Heliyon, 2017 - cell.com
Progress identifying the genetic determinants of personality has historically been slow, with
candidate gene studies and small-scale genome-wide association studies yielding few …

Genetics of impulsive behaviour

L Bevilacqua, D Goldman - Philosophical Transactions of …, 2013 - royalsocietypublishing.org
Impulsivity, defined as the tendency to act without foresight, comprises a multitude of
constructs and is associated with a variety of psychiatric disorders. Dissecting different …

Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction

MJ Kreek, DA Nielsen, ER Butelman… - Nature neuroscience, 2005 - nature.com
Genetic variation may partially underlie complex personality and physiological traits—such
as impulsivity, risk taking and stress responsivity—as well as a substantial proportion of …